Molecular Mimicry by γ-2 Herpesviruses to Modulate Host Cell Signaling Pathways

  • Lai-Yee WongEmail author
  • Zsolt Toth
  • Kevin F. Brulois
  • Kyung-Soo Inn
  • Sun Hwa Lee
  • Hye-Ra Lee
  • Jae U. Jung
Part of the Developments in Primatology: Progress and Prospects book series (DIPR)


Herpesviruses are large double-stranded DNA viruses that can establish life-long infection in their respective hosts and are capable of undergoing either latent or lytic replication. They are grouped into three subfamilies (α, β, and γ) based on their genome organization and biological characteristics. γ-Herpesviruses are oncogenic viruses capable of causing neoplasia in the infected host and contain multiple genes that contribute to virus-induced tumorigenesis. The ability of γ-herpesviruses to manipulate the lymphocyte activation pathways is particularly important to ensure their survival and concealment from host immune surveillance since they establish latent reservoirs within circulating lymphocytes. This chapter focuses on the unique viral genes located adjacent to the terminal ends of Kaposi’s sarcoma-associated herpesvirus (KSHV), herpesvirus saimiri (HVS), and rhesus rhadinovirus (RRV) genomes, three γ-Herpesviridae members that infect primates. Despite a lack of sequence similarity between these viral proteins, they are remarkably conserved in their structure and functions. In addition, this chapter covers some of the exciting studies on viral microRNAs (miRNAs) and their influence on both host cellular processes and the viral life cycle. Together, these viral proteins and miRNAs modulate multiple signaling pathways and contribute to viral-dependent proliferation phenotypes seen in infected organisms. Deciphering the virus-specific functions of these genes and miRNAs not only reveal the high level of molecular piracy among these viruses but may also shed light on how these complex virus–host interactions have shaped the coevolution of γ-herpesviruses and their respective primate hosts.


Common Marmoset Primary Effusion Lymphoma Lytic Replication Viral miRNAs Primary Effusion Lymphoma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Lai-Yee Wong
    • 1
    Email author
  • Zsolt Toth
    • 1
  • Kevin F. Brulois
    • 1
  • Kyung-Soo Inn
    • 1
  • Sun Hwa Lee
    • 1
  • Hye-Ra Lee
    • 1
  • Jae U. Jung
    • 1
  1. 1.Department of Molecular Microbiology and ImmunologyUniversity of Southern California, Keck School of MedicineLos AngelesUSA

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