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Vitamin D Fortification in North America: Current Status and Future Considerations

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Handbook of Food Fortification and Health

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Abstract

Until the last decade, adequacy of vitamin D status was not a public health concern, because vitamin D synthesis from sun exposure was thought to meet most of the North American populations’ needs and the ubiquitous fortification of milk was thought to provide sufficient intake when sun exposure was limited. More recently, a growing incidence of rickets in infants and evidence from national surveys showing high prevalence of poor vitamin D status in children and adults is slowly eroding our confidence in the vitamin D adequacy of many Americans and Canadians, as well as in other developed countries [1–3]. Concern about the high prevalence of poor vitamin D status stems from the significant association of low plasma 25-hydroxyvitamin D {25(OH)D} levels with the increased risk of both chronic and infectious disease, but most strongly with the chronic bone diseases, osteoporosis, and rickets in children [1–4].

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Abbreviations

1,25(OH)2D:

1,25-Dihydroxyvitamin D

25(OH)D:

25-Hydroxyvitamin D

AI:

Adequate intake

CHMS:

Canadian health measures survey

DRI:

Dietary Recommended Intake

EAR:

Estimated average requirement

IOM:

Institute of Medicine of the National Academy of Sciences

NHANES:

National Health and Nutrition Education Survey

RDA:

Recommended Daily Allowance

UL:

Upper level of safe intake

USDA:

US Department of Agriculture

Vitamin D2:

Ergocalciferol

Vitamin D3:

Cholecalciferol

References

  1. Whiting S, Calvo M. Lifestyle and nutritional determinants of vitamin status. In: Feldman D, Pike WJ, Adams JS, editors. Vitamin D. 3rd ed. San Diego, CA: Academic; 2011. p. 979–1007.

    Chapter  Google Scholar 

  2. Holick MF. Vitamin D, deficiency. New Engl J Med. 2007;357:266–81.

    Article  PubMed  CAS  Google Scholar 

  3. Holick M, Binkley N, Bischoff-Ferrari H, Gordon C, Hanley D, Heaney R, et al. Evaluation, treatment and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011;96:1911–30.

    Article  PubMed  CAS  Google Scholar 

  4. Van Schoor NM, Lips P. World wide vitamin D status. Best Pract Res Clin Endocrinol Metab. 2011;25:671–80.

    Article  PubMed  Google Scholar 

  5. Department of Agriculture, Department of Health and Human Services. Dietary guidelines for Americans 2010 [Internet]. Washington, DC: Government Printing Office; 2011 Jan 11. http://www.cnpp.usda.gov/DGAs2010-PolicyDocument.htm (last accessed 5 Aug 2011)

  6. Institute of Medicine, Food and Nutrition Board. Dietary reference intakes for calcium and vitamin D. Washington, DC: National Academy of Science (NAS), The National Academy Press; 2011.

    Google Scholar 

  7. Hanley DA, Cranney A, Jones G, Whiting SJ, Leslie WD, Cole DEC, et al. Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada. CMAJ. 2010;182:E610–8.

    Article  PubMed  Google Scholar 

  8. Whiting SJ, Green TJ, Calvo MS. Vitamin D intakes in in North America and Asia-Pacific countries are not sufficient to prevent vitamin D insufficiency. J Steroid Biochem Mol Biol. 2007;103:626–30.

    Article  PubMed  CAS  Google Scholar 

  9. Vatanparast H, Calvo MS, Green TJ, Whiting SJ. Despite mandatory fortification of staple foods, vitamin D intakes of Canadian children and adults are inadequate. J Steroid Biochem Mol Biol. 2010;121:301–3.

    Article  PubMed  CAS  Google Scholar 

  10. Calvo MS, Whiting SJ, Barton CN. Vitamin D fortification in the US and Canada: current status and research needs. Am J Clin Nutr. 2004;80:1710S–6.

    PubMed  CAS  Google Scholar 

  11. Calvo MS, Whiting SJ. Public health strategies to overcome barriers to optimal vitamin D status in populations with special needs. J Nutr. 2006;136:1135–9.

    PubMed  CAS  Google Scholar 

  12. O’Donnell S, Cranney A, Horsley T, Weiler HA, Atkinson SA, Hanley DA, et al. Efficacy of food fortification on serum 25-hydroxyvitamin D concentrations: systematic review. Am J Clin Nutr. 2008;88:1528–34.

    Article  PubMed  Google Scholar 

  13. O’Mahony L, Stepien M, Gibney MJ, Nugent AP, Brennan L. The potential role of vitamin D enhanced foods in improving vitamin D status. Nutrients. 2011;3:1023–41.

    Article  PubMed  Google Scholar 

  14. Calvo MS, Whiting SJ. Prevalence of vitamin D insufficiency in Canada and the United States: importance to health status and efficacy of current food fortification and dietary supplement use. Nutr Rev. 2003;61:107–13.

    Article  PubMed  Google Scholar 

  15. Looker AC, Pfeiffer CM, Lacher DA, Schleicher RL, Picciano MF, Yetley EA. Serum 25-hydroxyvitamin D status in the US population: 1988–1994 compared with 2000–2004. Am J Clin Nutr. 2008;88:1519–27.

    Article  PubMed  CAS  Google Scholar 

  16. Whiting SJ, Langlois KA, Vatanparast H, Greene-Finestone LS. The vitamin D status of Canadians relative to the 2011 Dietary Reference Intakes: an examination in children and adults with and without supplement use. Am J Clin Nutr. 2011;94:128–35.

    Article  PubMed  CAS  Google Scholar 

  17. Looker AC, Johnson CL, Lacher DA, Pfeiffer CM, Schleicher RL, Sempos CT. Vitamin D status: United States, 2001–2006. NCHS Data Brief no. 59. Hyattsville, MD: National Center for Health Statistics; 2011.

    Google Scholar 

  18. Institute of Medicine, Committee on Use of Dietary Reference Intakes in Nutrition Labeling. Dietary reference intakes: guiding principles for nutrition labeling and fortification. Washington, DC: The National Academies Press; 2003.

    Google Scholar 

  19. Fulgoni VL, Keast DR, Bailey RL, Dwyer J. Foods, fortificants, and supplements: where do Americans get their nutrients? J Nutr. 2011;141:1847–54.

    Article  PubMed  CAS  Google Scholar 

  20. Hayek EI, Egeland G, Weiler H. Vitamin D status in Inuit preschoolers reflects season and vitamin D intake. J Nutr. 2011;140:1839–45.

    Google Scholar 

  21. Calvo MS, Whiting MS, Barton CN. Vitamin D intake: a global perspective of current status. J Nutr. 2005;135:310–6.

    PubMed  CAS  Google Scholar 

  22. Langlois K, Greene-Finestone L, Little J, Hidiroglou N, Whiting SJ. Vitamin D status of Canadians as measured in the 2007 to 2009 Canadian Health Measures Survey. Health Rep 2010;21(1):47–55. Statistics Canada, Catalogue no. 82-003-XPE.

    Google Scholar 

  23. Cheney MC. Canadian experience with food fortification. Public Health Rev. 2000;28:171–7.

    PubMed  CAS  Google Scholar 

  24. Sacco JE, Tarasuk V. Health Canada’s proposed discretionary fortification policy is misaligned with the nutritional needs of Canadians. J Nutr. 2009;130:1980–6.

    Google Scholar 

  25. Sacco JE, Tarasuk V. Discretionary addition of vitamins and minerals to foods: implications for healthy eating. Eur J Clin Nutr. 2011;65:313–20.

    Article  PubMed  CAS  Google Scholar 

  26. Cranney A, Horsely T, O’Donnell S, Weiler H, Puil L, Ooi D, et al. Effectiveness and safety of vitamin D in relation to bone health. Evid Rep Technol Assess (Full Rep). 2009;128:1–235.

    Google Scholar 

  27. Harnack LJ, Steffen L, Zhou X, Luepker RV. Trends in vitamin D intake from food sources among adults in the Minneapolis-St Paul, MN, Metropolitan area, 1980–1982 through 2007–2009. J Am Diet Assoc. 2011;111:1329–34.

    Article  PubMed  CAS  Google Scholar 

  28. Calvo MS, Babu US, Garthoff LH, Woods TO, Dreher M, Hill G, Nagaraja S. Vitamin D2 from light-exposed edible mushrooms is safe, bioavailable and effectively supports bone growth in rats. Osteoporos Int. 2013;24:197–207.

    Google Scholar 

  29. Kalaras MD, Beelman RB, Elias RJ. Effects of post-harvest pulsed UVlight treatment of white button mushrooms (Agaricus bisporusr) on Vitamin D2 content and quantity attributes. J Agric Food Chem. 2012;60:220–5.

    Article  PubMed  CAS  Google Scholar 

  30. Urbain P, Singler F, Ihorst G, Biesalski HK, Bertz H. Bioavailability of vitamin D2 from UV-B-irradiated button mushrooms in healthy adults deficient in serum 25-hydroxyvitamin D: a randomized controlled trial. Eur J Clin Nutr. 2011;65:965–71.

    Article  PubMed  CAS  Google Scholar 

  31. Ozzard A, Hear G, Morrison G, Hoskin M. Vitamin D deficiency treated by consuming UVB-irradiated mushrooms. Br J Gen Pract. 2009;58:644–5.

    Article  Google Scholar 

  32. Mattila P, Valkonen E, Valaja J. Effect of different vitamin D supplementations in poultry feed on vitamin D supplementations in poultry feed on vitamin D content of eggs and chicken meat. J Agric Food Chem. 2011;59:8298–303.

    Article  PubMed  CAS  Google Scholar 

  33. Lock E-J, Waagbro R, Wendelaar Bonga S, Flik G. The significance of vitamin D for fish: a review. Aquacult Nutr. 2010;16:100–16.

    Article  CAS  Google Scholar 

  34. Hollis B. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr. 2005;135:317–22.

    PubMed  CAS  Google Scholar 

  35. Carpenter TO, Herreros F, Zhang JH, Ellis BK, Simpson C, Torrealba-Fox E, et al. Demographic, dietary, and biochemical determinants of vitamin D status in inner-city children. Am J Clin Nutr. 2012;95:137–46.

    Article  PubMed  CAS  Google Scholar 

  36. Houghton LA, Gray AR, Szymelek-Gay EA, Heath A-LM, Ferguson EL. Vitamin D fortified milk achieves the targeted serum 25-hydroxyvitamin D concentration without affecting that of parathyroid hormone in New Zealand toddlers. J Nutr. 2011;141:1840–6.

    Article  PubMed  CAS  Google Scholar 

  37. Chan GM, Hoffman K, McMurry M. Effects of dairy products on bone and body composition in pubertal girls. J Pediatr. 1995;126:551–6.

    Article  PubMed  CAS  Google Scholar 

  38. Rich-Edwards JW, Ganmaa D, Kleinnman K, Sumberzul N, Holick MF, Lkhagvasuren T, et al. Randomized trial of fortified milk and supplements to raise 25-hydroxyvitamin D concentrations in schoolchildren in Mongolia. Am J Clin Nutr. 2011;94:578–84.

    Article  PubMed  CAS  Google Scholar 

  39. Green TJ, Skeaff CM, Rockell JE. Milk fortified with the current adequate intake for vitamin D (5 μg) increases serum 25-hydroxyvitamin D compared to control milk but is not sufficient to prevent a seasonal decline in young women. Asia Pac J Clin Nutr. 2010;19:195–9.

    PubMed  CAS  Google Scholar 

  40. Daly RM, Brown M, Bass SA, Kukuljan S, Nowson C. Calcium and vitamin 3-fortified milk reduces bone loss at clinically relevant skeletal sites in older men: a 2-year randomized controlled trial. J Bone Miner Res. 2006;21:397–405.

    Article  PubMed  CAS  Google Scholar 

  41. Nikooyeh B, Neyestani TR, Farvid M, Alavi-Majd H, Houshiarrad A, Kalayi A, et al. Daily consumption of vitamin D− or vitamin D+ calcium-fortified yogurt drink improved glycemic control in patients with type 2 diabetes: a randomized clinical trial. Am J Clin Nutr. 2011;94:764–71.

    Article  Google Scholar 

  42. Johnson JL, Mistry VV, Vukovich MD, Hogie-Lorenzen T, Hollis BW, Specker BL. Bioavailability of vitamin D from fortified process cheese and effects of vitamin D status in the elderly. J Dairy Sci. 2005;88:2295–301.

    Article  PubMed  CAS  Google Scholar 

  43. Wagner D, Sidhom G, Whiting SJ, Rousseau D, Vieth R. The bioavailability of vitamin D from fortified cheese and supplements is equivalent in adults. J Nutr. 2008;138:1365–71.

    PubMed  CAS  Google Scholar 

  44. Natri A-M, Salo P, Vikstedt T, Palssa A, Huttunen M, Käarkäaiinen MUM, et al. Bread fortified with cholecalciferol increases the serum 25-hydroxyvitmain D concentration in women as effectively as a cholecalciferol supplement. J Nutr. 2006;136:123–7.

    PubMed  CAS  Google Scholar 

  45. Mocanu V, Stitt PA, Costan AR, Voroniuc O, Zbranca E, Luca V, et al. Long-term effects of giving nursing home residents bread fortified with 125 micrograms (5000 IU) vitamin D(3) per daily serving. Am J Clin Nutr. 2009;89:1132–7.

    Article  PubMed  CAS  Google Scholar 

  46. Biancuzzo R, Young A, Bilbuld D, Cai M, Winter M, Klein E, et al. Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults. Am J Clin Nutr. 2010;91:1621–6.

    Article  PubMed  CAS  Google Scholar 

  47. Tangpricha V, Koutkia P, Rieke SM, Chen TC, Perez AA, Holick MF. Fortification of orange juice with vitamin D: a novel approach for enhancing vitamin D nutritional health. Am J Clin Nutr. 2003;77:1478–83.

    PubMed  CAS  Google Scholar 

  48. Adolphe JL, Whiting SJ, Dahl WJ. Vitamin D fortification of purréed foods for long-term care residents. Can J Diet Pract Res. 2009;70:143–50.

    Article  PubMed  Google Scholar 

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Correspondence to Mona S. Calvo PhD .

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Calvo, M.S., Whiting, S.J. (2013). Vitamin D Fortification in North America: Current Status and Future Considerations. In: Preedy, V., Srirajaskanthan, R., Patel, V. (eds) Handbook of Food Fortification and Health. Nutrition and Health. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-7110-3_21

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  • DOI: https://doi.org/10.1007/978-1-4614-7110-3_21

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