Regulation of Immunological Responses by the Neonatal Fc Receptor for IgG, FcRn



Immunoglobulins (Ig) are the hallmark of the humoral immune system and can be found, in varying concentrations, in all tissues of the body as well as throughout the circulatory system. Of the various isotypes, IgG is by far the most abundant in serum due to its extremely long half-life of 7–23 days. Indeed, while other Ig isotypes are known for very specialized roles in allergy (IgE) and pathogen neutralization (IgA), IgG is the main driver of many of the functions originally attributed to humoral immunity including opsonization, complement activation, and antibody-dependent cellular cytotoxicity (ADCC). Increasingly, however, it is being recognized that the functions of IgG extend beyond simply that of a humoral immune system component to that of a potent integrator of the humoral and cellular arms of a coordinated adaptive immune response.


Immunoglobulins Humoral immune system IgG Immunological responses Fc receptor Antibody-dependent cellular cytotoxicity FcRn Intracellular trafficking Regulation of IgG 



This work was supported by the Canadian Institutes of Health Research, the Deutsche Forschungsgemeinschaft (RA 2040/1–1), the High Pointe Foundation, the National Institutes of Health Research (DK53056, DK053162, DK088199, and DK044319), and the Harvard Digestive Diseases Center (NIH P30DK034854).


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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Division of Gastroenterology, Hepatology and EndoscopyBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Division of Gastroenterology, Hepatology and EndoscopyHarvard Medical School and Brigham and Women’s HospitalBostonUSA

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