Myoepithelial Tumors

  • Cyril Fisher
Chapter
Part of the Atlas of Anatomic Pathology book series (AAP)

Abstract

Soft tissue neoplasms that display myoepithelial differentiation have a range of appearances similar to those arising in the salivary glands, with fascicular or trabecular architecture and epithelioid, clear cell, plasmacytoid, or spindled cytomorphology. Mixed tumors are defined by additionally having ductules or chondroid stroma. This category now includes tumors formerly termed parachordoma, although there are subtle differences between the two entities, and possibly some occurrences of ectomesenchymal chondromyxoid tumor, a very rare lesion of the anterior tongue. Ectopic hamartomatous thymoma (see Chap. 15) also has some features suggestive of myoepithelial differentiation.

Suggested Reading

  1. Allen CM. The ectomesenchymal chondromyxoid tumor: a review. Oral Dis. 2008;14:390–5.PubMedCrossRefGoogle Scholar
  2. Antonescu CR, Zhang L, Chang NE, Pawel BR, Travis W, Katabi N, et al. EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene. Genes Chromosomes Cancer. 2010;49:1114–24.PubMedCrossRefGoogle Scholar
  3. Fisher C. Parachordoma exists—but what is it? Adv Anat Pathol. 2000;7:141–8.PubMedCrossRefGoogle Scholar
  4. Hornick JL, Fletcher CD. Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters. Am J Surg Pathol. 2003;27:1183–96.PubMedCrossRefGoogle Scholar
  5. Kilpatrick SE, Limon J. Mixed tumour/myoepithelioma/parachordoma. In: Fletcher CD, Unni K, Mertens F, editors. WHO classification of tumours. Pathology and genetics. Tumours of soft tissue and bone. Lyon: IARC Press; 2002. p. 198–9.Google Scholar
  6. Mentzel T, Requena L, Kaddu S, Soares de Aleida LM, Sangueza OP, Kutzner H. Cutaneous myoepithelial neoplasms: clinicopathologic and immunohistochemical study of 20 cases suggesting a continuous spectrum ranging from benign mixed tumor of the skin to cutaneous myoepithelioma and myoepithelial carcinoma. J Cutan Pathol. 2003;30:294–302.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Cyril Fisher
    • 1
  1. 1.Department of HistopathologyThe Royal Marsden HospitalLondonUK

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