Benign Fibroblastic and Myofibroblastic Lesions
A large group of relatively common soft tissue tumors are composed of a mixture of fibroblasts and myofibroblasts. Fibroblasts are slender cells with elongated tapered or serpiginous nuclei and little cytoplasm. Myofibroblasts tend to be plumper and have oval nuclei, each with a small distinct nucleolus, and variable amounts of amphophilic cytoplasm according to the functional state of the cells. Both have contractile and (stromal) secretory properties and can modulate into fibroblasts. Cell margins are poorly defined and tend to blend into adjacent collagen. Nuclear pleomorphism sometimes is a feature in both reactive and neoplastic conditions.
KeywordsSclerosing Cholangitis Autoimmune Pancreatitis Nuclear Pleomorphism Serum IgG4 Level Cell Margin
- Fletcher C, Unni K, Mertens F, editors. World Health Organization classification of tumours. Pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press; 2002.Google Scholar