Tumors of Uncertain Differentiation

  • Cyril Fisher
Chapter
Part of the Atlas of Anatomic Pathology book series (AAP)

Abstract

Tumors of uncertain differentiation include benign and malignant neoplasms with distinctive features but uncertain lineage. Many have consistent genetic aberrations, and this category includes an increasing number of translocation-associated benign soft tissue tumors and sarcomas. Although they sometimes express antigens more characteristic of specific tumor types, such as carcinoma or melanoma, these neoplasms usually do not correspond to any normal cell type and can be regarded as new lineages with characteristic patterns of gene expression. Translocation-associated soft tissue sarcomas, when they have a reciprocal translocation resulting in diploid cells, typically lack nuclear pleomorphism, yet they often are aggressive high-grade sarcomas.

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Cyril Fisher
    • 1
  1. 1.Department of HistopathologyThe Royal Marsden HospitalLondonUK

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