Smooth Muscle Tumors

  • Cyril Fisher
Chapter
Part of the Atlas of Anatomic Pathology book series (AAP)

Abstract

Tumors of smooth muscle cells are relatively common. They occur in skin and in superficial and deep soft tissues, including the retroperitoneum and the paratesticular region. Clinically distinctive smooth muscle tumors also arise in the male and female genital tracts, head and neck region, and viscera, including gastrointestinal sites. However, in the abdomen they now are diagnosed less frequently than in the past owing to the recognition of gastrointestinal stromal tumor (GIST). Most smooth muscle tumors arise spontaneously, and there are no consistent translocations. A t(7;8)(p13;q11.2) has been described in a leiomyoma of the vulva. Rare hereditary leiomyomas are associated with mutations in the MCUL-1 gene that encodes fumarate dehydrogenase. Epstein-Barr virus (EBV)-associated smooth muscle tumors may arise in immunosuppressed individuals, and leiomyosarcomas are one of the more common histologic subtypes of postradiation sarcoma.

Suggested Reading

  1. Billings SD, Folpe AL, Weiss SW. Do leiomyomas of deep soft tissue exist? An analysis of highly differentiated smooth muscle tumors of deep soft tissue supporting two distinct subtypes. Am J Surg Pathol. 2001;25:1134–42.PubMedCrossRefGoogle Scholar
  2. Deyrup AT, Haydon RC, Huo D, Ishikawa A, Peabody TD, He TC, et al. Myoid differentiation and prognosis in adult pleomorphic sarcomas of the extremity: an analysis of 92 cases. Cancer. 2003;98:805–13.PubMedCrossRefGoogle Scholar
  3. Deyrup AT, Lee VK, Hill CE, Cheuk W, Toh HC, Kesavan S, et al. Epstein–Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. Am J Surg Pathol. 2006;30:75–82.PubMedCrossRefGoogle Scholar
  4. Eyden B, Chorneyko KA. Intranodal myofibroblastoma: study of a case suggesting smooth-muscle differentiation. J Submicrosc Cytol Pathol. 2001;33:157–63.PubMedGoogle Scholar
  5. Fisher C, Goldblum JR, Epstein JI, Montgomery E. Leiomyosarcoma of the paratesticular region: a clinicopathologic study. Am J Surg Pathol. 2001;25:1143–9.PubMedCrossRefGoogle Scholar
  6. Horton E, Dobin SM, DebiecRychter M, Donner LR. A clonal translocation (7;8)(p13;q11.2) in a leiomyoma of the vulva. Cancer Genet Cytogenet. 2006;170:58–60.PubMedCrossRefGoogle Scholar
  7. Kraft S, Fletcher CD. Atypical intradermal smooth muscle neoplasms: clinicopathologic analysis of 84 cases and a reappraisal of cutaneous “leiomyosarcoma”. Am J Surg Pathol. 2011;35:599–607.PubMedCrossRefGoogle Scholar
  8. Lehtonen HJ, Kiuru M, Ylisaukko-Oja SK, Salovaara R, Herva R, Koivisto PA, et al. Increased risk of cancer in patients with fumarate hydratase germline mutation. J Med Genet. 2006;43:523–6.PubMedCrossRefGoogle Scholar
  9. Maggiani F, Debiec-Rychter M, Verbeeck G, Sciot R. Extramammary myofibroblastoma is genetically related to spindle cell lipoma. Virchows Arch. 2006;449:244–7.PubMedCrossRefGoogle Scholar
  10. Massi D, Beltrami G, Capanna R, Franchi A. Histopathological re-classification of extremity pleomorphic soft tissue sarcoma has clinical relevance. Eur J Surg Oncol. 2004;30:1131–6.PubMedCrossRefGoogle Scholar
  11. Massi D, Franchi A, Alos L, Cook M, Di Palma S, Enguita AB, et al. Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases. Histopathology. 2010;56:251–62.PubMedCrossRefGoogle Scholar
  12. Matsuyama A, Hisaoka M, Hashimoto H. Angioleiomyoma: a clinicopathologic and immunohistochemical reappraisal with special reference to the correlation with myopericytoma. Hum Pathol. 2007;38:645–51.PubMedCrossRefGoogle Scholar
  13. McMenamin ME, Fletcher CD. Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma. Am J Surg Pathol. 2001;25:1022–9.PubMedCrossRefGoogle Scholar
  14. Meis JM, Enzinger FM. Myolipoma of soft tissue. Am J Surg Pathol. 1991;15:121–5.PubMedCrossRefGoogle Scholar
  15. Michal M, Chlumska A, Skalova A, Fakan F. Palisaded intranodal myofibroblastoma. Electron microscopic study. Zentralbl Pathol. 1993;139:81–8.PubMedGoogle Scholar
  16. Montgomery E, Goldblum JR, Fisher C. Leiomyosarcoma of the head and neck: a clinicopathological study. Histopathology. 2002;40:518–25.PubMedCrossRefGoogle Scholar
  17. Neuhaus SJ, Pinnock N, Giblin V, Fisher C, Thway K, Thomas JM, et al. Treatment and outcome of radiation-induced soft-tissue sarcomas at a specialist institution. Eur J Surg Oncol. 2009;35:654–9.PubMedCrossRefGoogle Scholar
  18. Nguyen T, Eltorky MA. Intranodal palisaded myofibroblastoma. Arch Pathol Lab Med. 2007;131:306–10.PubMedGoogle Scholar
  19. Oda Y, Miyajima K, Kawaguchi K, Tamiya S, Oshiro Y, Hachitanda Y, et al. Pleomorphic leiomyosarcoma: clinicopathologic and immunohistochemical study with special emphasis on its distinction from ordinary leiomyosarcoma and malignant fibrous histiocytoma. Am J Surg Pathol. 2001;25:1030–8.PubMedCrossRefGoogle Scholar
  20. Paal E, Miettinen M. Retroperitoneal leiomyomas: a clinicopathologic and immunohistochemical study of 56 cases with a comparison to retroperitoneal leiomyosarcomas. Am J Surg Pathol. 2001;25:1355–63.PubMedCrossRefGoogle Scholar
  21. Suster S, Rosai J. Intranodal hemorrhagic spindle-cell tumor with “amianthoid” fibers. Report of six cases of a distinctive mesenchymal neoplasm of the inguinal region that simulates Kaposi’s sarcoma. Am J Surg Pathol. 1989;13:347–57.PubMedCrossRefGoogle Scholar
  22. Weiss SW. Smooth muscle tumors of soft tissue. Adv Anat Pathol. 2002;9:351–9.PubMedCrossRefGoogle Scholar
  23. Weiss SW, Gnepp DR, Bratthauer GL. Palisaded myofibroblastoma. A benign mesenchymal tumor of lymph node. Am J Surg Pathol. 1989;13:341–6.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Cyril Fisher
    • 1
  1. 1.Department of HistopathologyThe Royal Marsden HospitalLondonUK

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