Neuroectodermal and Neural Tumors
The category of neuroectodermal and neural tumors includes tumors outside the central nervous system, supposedly derived from primitive neural crest cells, in which the principal line of differentiation is neuroectodermal, or toward nerve cells (as opposed to cells of the nerve sheath). These tumors also sometimes have neuroendocrine features, although many are undifferentiated. The less differentiated neoplasms tend to occur in childhood and include Ewing sarcoma and neuroblastoma.
Ewing sarcoma and primitive peripheral neuroectodermal tumor are small round cell malignant neoplasms that are essentially the same entity but are considered to display a spectrum of neuroectodermal differences, mostly at the ultrastructural or immunohistochemical level.
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