Tumors of Adipose Tissue

  • Cyril Fisher
Chapter
Part of the Atlas of Anatomic Pathology book series (AAP)

Abstract

Tumors of adipose tissue are the most frequently encountered benign or malignant soft tissue tumors. Lipomas may occur at almost any site and represent the most common benign soft tissue neoplasm. Liposarcoma has a high incidence among malignant soft tissue tumors, but the term includes several distinct lipogenic tumor types that vary clinically, histogenetically, and genetically. These include tumors with increased copy numbers (gene amplification), specific translocations, or complex karyotypes, but there are no significant predisposing factors.

Lipoblasts are a distinctive feature of some liposarcomas, but their presence is not necessary for the microscopic diagnosis of well-differentiated liposarcomas or myxoid liposarcomas.

Keywords

Sarcoma Lipoma Liposarcomas 

Suggested Reading

  1. Bassett MD, Schuetze SM, Disteche C, Norwood TH, Swisshelm K, Chen X, et al. Deep-seated, well differentiated lipomatous tumors of the chest wall and extremities: the role of cytogenetics in classification and prognostication. Cancer. 2005;103:409–16.PubMedCrossRefGoogle Scholar
  2. Bejia I, Younes M, Moussa A, Said M, Touzi M, Bergaoui N. Lipoma arborescens affecting multiple joints. Skeletal Radiol. 2005;34:536–8.PubMedCrossRefGoogle Scholar
  3. Coffin CM. Lipoblastoma: an embryonal tumor of soft tissue related to organogenesis. Semin Diagn Pathol. 1994;11:98–103.PubMedGoogle Scholar
  4. Dal Cin P, Sciot R, De Wever I, Van Damme B, Van den Berghe H. New discriminative chromosomal marker in adipose tissue tumors. The chromosome 8q11-q13 region in lipoblastoma. Cancer Genet Cytogenet. 1994;78:232–5.PubMedCrossRefGoogle Scholar
  5. Davies AP, Blewitt N. Lipoma arborescens of the knee. Knee. 2005;12:394–6.PubMedCrossRefGoogle Scholar
  6. Dei Tos AP, Mentzel T, Newman PL, Fletcher CD. Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Analysis of six cases. Am J Surg Pathol. 1994;18:913–21.PubMedCrossRefGoogle Scholar
  7. El-Mekresh MM, Abdel-Gawad M, El-Diasty T, El-Baz M, Ghoneim MA. Clinical, radiological and histological features of adrenal myelolipoma: review and experience with a further eight cases. Br J Urol. 1996;78:345–50.PubMedCrossRefGoogle Scholar
  8. Enzinger FM, Harvey DA. Spindle cell lipoma. Cancer. 1975;36:1852–9.PubMedCrossRefGoogle Scholar
  9. Fowler MR, Williams RB, Alba JM, Byrd CR. Extra-adrenal myelolipomas compared with extramedullary hematopoietic tumors: a case of presacral myelolipoma. Am J Surg Pathol. 1982;6:363–74.PubMedCrossRefGoogle Scholar
  10. Furlong MA, Fanburg-Smith JC, Miettinen M. The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases. Am J Surg Pathol. 2001;25:809–14, 19.PubMedCrossRefGoogle Scholar
  11. Golledge J, Fisher C, Rhys-Evans PH. Head and neck liposarcoma. Cancer. 1995;76:1051–8.PubMedCrossRefGoogle Scholar
  12. Hawley IC, Krausz T, Evans DJ, Fletcher CD. Spindle cell lipoma—a pseudoangiomatous variant. Histopathology. 1994;24:565–9.PubMedCrossRefGoogle Scholar
  13. Huang D, Sumegi J, Dal Cin P, Reith JD, Yasuda T, Nelson M, et al. C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. Genes Chromosomes Cancer. 2010;49:810–8.PubMedGoogle Scholar
  14. Hunt SJ, Santa Cruz DJ, Barr RJ. Cellular angiolipoma. Am J Surg Pathol. 1990;14:75–81.PubMedCrossRefGoogle Scholar
  15. Lam KY, Lo CY. Adrenal lipomatous tumours: a 30 year clinicopathological experience at a single institution. J Clin Pathol. 2001;54:707–12.PubMedCrossRefGoogle Scholar
  16. Mandahl N, Mertens F, Willen H, Rydholm A, Brosjo O, Mitelman F. A new cytogenetic subgroup in lipomas: loss of chromosome 16 material in spindle cell and pleomorphic lipomas. J Cancer Res Clin Oncol. 1994;120:707–11.PubMedCrossRefGoogle Scholar
  17. Meis JM, Enzinger FM. Myolipoma of soft tissue. Am J Surg Pathol. 1991;15:121–5.PubMedCrossRefGoogle Scholar
  18. Meis JM, Enzinger FM. Chondroid lipoma. A unique tumor simulating liposarcoma and myxoid chondrosarcoma. Am J Surg Pathol. 1993;17:1103–12.PubMedCrossRefGoogle Scholar
  19. Meis-Kindblom JM, Kindblom LG. Acral myxoinflammatory fibroblastic sarcoma: a low-grade tumor of the hands and feet. Am J Surg Pathol. 1998;22:911–24.PubMedCrossRefGoogle Scholar
  20. Mentzel T, Palmedo G, Kuhnen C. Well-differentiated spindle cell liposarcoma (‘atypical spindle cell lipomatous tumor’) does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases. Mod Pathol. 2010;23:729–36.PubMedCrossRefGoogle Scholar
  21. Mertens F, Rydholm A, Brosjo O, Willen H, Mitelman F, Mandahl N. Hibernomas are characterized by rearrangements of chromosome bands 11q13-21. Int J Cancer. 1994;58:503–5.PubMedCrossRefGoogle Scholar
  22. Shmookler BM, Enzinger FM. Pleomorphic lipoma: a benign tumor simulating liposarcoma. A clinicopathologic analysis of 48 cases. Cancer. 1981;47:126–33.PubMedCrossRefGoogle Scholar
  23. Suster S, Fisher C, Moran CA. Dendritic fibromyxolipoma: clinicopathologic study of a distinctive benign soft tissue lesion that may be mistaken for a sarcoma. Ann Diagn Pathol. 1998;2:111–20.PubMedCrossRefGoogle Scholar
  24. Thway K, Flora R, Shah C, Olmos D, Fisher C. Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors. Am J Surg Pathol. 2012;36:462–9.PubMedCrossRefGoogle Scholar
  25. Weiss SW, Enzinger FM. Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Cancer. 1982;50:970–81.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Cyril Fisher
    • 1
  1. 1.Department of HistopathologyThe Royal Marsden HospitalLondonUK

Personalised recommendations