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Cellular and Molecular Mechanisms of Resveratrol and Its Derivatives

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Bioactive Polyphenols from Wine Grapes

Part of the book series: SpringerBriefs in Cell Biology ((SBCB))

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Abstract

The cellular mechanisms and proximal targets responsible for resveratrol’s biological activity in mammalian cells are a subject of continued debate amongst the scientific community. One of the earliest activities attributed to resveratrol was that of an estrogen receptor agonist. In this chapter we highlight the striking parallels that exist between the effects elicited by resveratrol and its derivatives, and those associated with estrogen, under a variety of experimental conditions. We discuss other prevalent mechanisms that have been put forward to account for resveratrol’s cellular and systemic effects, including direct interactions with sirtuins, AMPK activation, and phosphodiesterase inhibition. In each instance we relate these mechanisms to estrogen signalling pathways, and build the argument that resveratrol’s properties as an estrogen receptor agonist are central to its biological activities.

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  1. Department of Biological Sciences, Brock University, St. Catharines, ON, Canada

    Jeffrey A. Stuart & Ellen L. Robb

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Stuart, J.A., Robb, E.L. (2013). Cellular and Molecular Mechanisms of Resveratrol and Its Derivatives. In: Bioactive Polyphenols from Wine Grapes. SpringerBriefs in Cell Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6968-1_3

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