Functional Connectivity MRI in Autism

  • Jeffrey S. AndersonEmail author


Functional connectivity MRI (fcMRI) is a technique that examines the synchrony of repeated functional MRI (fMRI) measurements between two or more brain regions. The underlying concept is that even random “noise” in a brain region will get propagated to other connected brain areas and that this will result in synchronized patterns of activation that are specific to functionally connected brain networks. The fcMRI literature in autism has proliferated rapidly, with general, although not uniform evidence of underconnectivity in distributed brain networks in autism. Studies to date are heterogeneous, some using an underlying cognitive task and others not; some examine specific neural pathways and others examine large networks or the entire brain. Abnormalities are most apparent in distributed networks in association cortex, with the default mode network being the most commonly reported abnormal network. Future studies will greatly benefit from data-sharing initiatives such as the Autism Brain Imaging Data Exchange (ABIDE) and National Database for Autism Research (NDAR). Despite lingering methodological concerns, there is reason for optimism that replicable patterns of abnormal brain connectivity may be established in the near future.


Functional Connectivity Default Mode Network Inferior Parietal Lobule Anterior Insula Salience Network 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer New York 2013

Authors and Affiliations

  1. 1.Department of RadiologyUniversity of UtahSalt Lake CityUSA

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