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Inflammation, Obesity, and Colon Cancer

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Obesity, Inflammation and Cancer

Part of the book series: Energy Balance and Cancer ((EBAC,volume 7))

Abstract

The general focus of this chapter is to overview the contribution of obesity-­induced intestinal inflammation to colorectal cancer (CRC) incidence. Using inflammatory bowel disease as a model, the mechanisms by which gastrointestinal microbes and obesity-associated, adipose-derived mediators of inflammatory increase CRC risk will be discussed. Particular emphasis will be placed on the direct impact of these factors on intestinal epithelial cell proliferation, survival, and neoplastic transformation. Additionally, the influence of inflammatory factors on immune cell function and the indirect effect of altered immunity on intestinal epithelial cell proliferation and survival, and CRC risk will be explored.

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  1. Department of Genetics, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH, 44106-4915, USA

    Stephanie K. Doerner Ph.D.

  2. Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, MS BCM225, Houston, TX, 77030, USA

    Jason D. Heaney Ph.D.

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    Andrew J. Dannenberg

  2. School of Medicine, Center for Science, Health & Society, Case Western Reserve University, Euclid Ave. 10900, Cleveland, 44106, Ohio, USA

    Nathan A. Berger

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Doerner, S.K., Heaney, J.D. (2013). Inflammation, Obesity, and Colon Cancer. In: Dannenberg, A., Berger, N. (eds) Obesity, Inflammation and Cancer. Energy Balance and Cancer, vol 7. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6819-6_7

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