A Cell Culture System with Programmable Physical Stimulation for Human Mesenchymal Stem Cell Differentiation and Promotion

  • Tzu-Yu Chuang
  • Yu-Sheng Chuang
  • Nancy Wang
  • Kerwin Wang
Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 234)


It is important to study the osteoblast and chondrocyte differentiations of human mesenchymal stem cells (hMSCs) due to a significant demand for prerequisite regenerative medicine. Many physical stimulators would also promote cell differentiation. This study presents a time-efficient cell differentiation system to induce and evaluate the stem cell differentiation process under given physical stimulations. In this system, all the driving signals of physical stimulations can be controlled independently by a reprogrammable microcomputer for physical stimulation studies. This chapter focuses on the design methodology and characterization of this cell culture system.


hMSCs Cell culture Programmable Physical stimulation 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Tzu-Yu Chuang
    • 1
  • Yu-Sheng Chuang
    • 1
  • Nancy Wang
    • 2
  • Kerwin Wang
    • 1
  1. 1.Department of Mechatronics EngineeringNational Changhua University of EducationChanghuaTaiwan
  2. 2.Graduate Institute of BiotechnologyNational Changhua University of EducationChanghuaTaiwan

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