Abstract
Chromosomal abnormalities represent the largest category of causes of death in humans. Abortuses that have reached a 2-week stage of development are estimated to have a 78 % rate of chromosomal abnormalities; however, this rate declines to 62 % for abortions occurring after the first missed menstrual period but before the 20th week. The proportion of fetuses with chromosomal defects drops continuously, with only 6 % of stillborn infants having a chromosome defect. The frequency of major chromosomal abnormalities in spontaneous abortions, the incidence in live-born infants, and the mechanism of chromosomal defects are discussed in this chapter.
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Gilbert-Barness, E., Spicer, D.E., Steffensen, T.S. (2014). Chromosomal Defects. In: Handbook of Pediatric Autopsy Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6711-3_6
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DOI: https://doi.org/10.1007/978-1-4614-6711-3_6
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