Hypogonadism: Evaluation

  • John P. Mulhall
  • Peter J. Stahl
  • Doron S. Stember


Hypogonadism (HG), also referred to as testosterone (T) deficiency, refers to a clinical syndrome that results from insufficient serum levels of T to effect adequate action in androgen-sensitive tissues.


Luteinizing Hormone Klinefelter Syndrome Testosterone Replacement Therapy Idiopathic Hypogonadotropic Hypogonadism Serum Luteinizing Hormone Level 
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Suggested Reading

  1. Araujo AB, Esche GR, Kupelian V, et al. Prevalence of symptomatic androgen deficiency in men. J Clin Endocrinol Metab. 2007;92:4241–7.PubMedCrossRefGoogle Scholar
  2. Arver S, Lehtihet M. Current guidelines for the diagnosis of testosterone deficiency. Front Horm Res. 2009;37:5–20.PubMedCrossRefGoogle Scholar
  3. Cohen PG. Pitfalls in the diagnosis of testosterone deficiency. Aging Male. 2008;11(2):49–50.PubMedCrossRefGoogle Scholar
  4. Ghanem HM, Salonia A, Martin-Morales A. Physical examination and laboratory testing for men with ED. J Sex Med. 2012.Google Scholar
  5. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endo Metab. 2001;86:724–31.CrossRefGoogle Scholar
  6. Morales A, Lunenfeld B. International Society for the Study of the Aging Male: investigation, treatment and monitoring of late-onset hypogonadism in males. Aging Male. 2002;5(2):74–86.PubMedGoogle Scholar
  7. Morales A, Collier CP, Clark AF. A critical appraisal of accuracy and cost of laboratory methodologies for the diagnosis of hypogonadism: the role of free testosterone assays. Can J Urol. 2012;19(3):6314–8.PubMedGoogle Scholar
  8. Morley JE, Charlton E, Patrick P, Kaiser FE. Validation of a screening questionnaire for androgen deficiency in aging males. Metabolism. 2000;49:1239–42.PubMedCrossRefGoogle Scholar
  9. Petak SM, Nankin HR, Spark RF, Swerdloff RS, Rodriguez-Rigau LJ. American Association of Clinical Endocrinologists. Medical guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients. Endocr Pract. 2002;8(6): 440–56.PubMedGoogle Scholar
  10. Shores MM, Matsumoto AM, Sloan KL, Kivlahan DR. Low serum testosterone and mortality in male veterans. Arch Intern Med. 2006;166:1660–5.PubMedCrossRefGoogle Scholar
  11. Sokol RZ. Endocrinology of male infertility: evaluation and treatment. Semin Reprod Med. 2009;27(2): 149–58.PubMedCrossRefGoogle Scholar
  12. Young J. Approach to the male patient with congenital hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2012;97(3):707–18.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • John P. Mulhall
    • 1
  • Peter J. Stahl
    • 2
  • Doron S. Stember
    • 3
  1. 1.Sexual and Reprodictive Medicine Program Department of Surgery Division of Urology, Department of SurgeryMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.Department of UrologyColumbia University College of Physicians & SurgeonsNew YorkUSA
  3. 3.Department of UrologyBeth Israel Medical Center Albert Einstein College of Medicine of Yeshiva UniversityNew YorkUSA

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