Abstract
There are three main progestin-only contraceptives (POCs) available in the United States: progestin-only pills (containing norethindrone acetate), injectable depot medroxy progesterone acetate (DMPA or Depo-Provera® IM and SC forms) and the etonogestrel implant (Implanon® NEXPLANON®). POCs have advantages over combination methods for female adolescents with contraindications to estrogens because POCs carry very few cardiovascular risks and do not increase risk for thromboembolism. DMPA is particularly beneficial for female adolescents with sickle cell disease, seizure disorder, and for those taking anticonvulsants and other cytochrome p450 inducing medications. POCs also avoid adverse effects attributed to estrogens such as nausea, headache, edema and breast tenderness that often lead to poor adherence. Both DMPA and the etonogestrel implants are long-acting, convenient, discreet, and cost-effective methods that are highly desirable by female adolescents who may have difficulties adhering to coital, daily, weekly, or monthly, more user-dependent methods. POCs offer a safe, reversible, and effective alternative to combination contraceptive methods, with particular benefits and without the adverse effects or health risks associated with exogenous estrogens.
Keywords
- Contraceptive Method
- Emergency Contraception
- Cervical Mucus
- Luteinizing Hormone Surge
- Young Adult Woman
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, access via your institution.
Buying options


References
Centers for Disease Control and Prevention. U.S. medical eligibility criteria for contraceptive use, 2010. MMWR. 2010;59(RR-4):1–86.
Grove D, Hooper DJ. Doctor contraceptive-prescribing behavior and women’s attitudes towards contraception: two European. J Eval Clin Pract. 2011;17(3):493–502.
Ahrendt HJ, Adolf D, Buhling KJ. Advantages and challenges of estrogen-free hormonal contraception. Curr Med Res Opin. 2010;26(8):1947–55.
Hatcher RA, Trussell J, Nelson AL, Cates Jr W, Stewar FH, Kowal D. Contraceptive technology. 19 revisedth ed. New York: Contraceptive Technology Communications, Inc.; 2007.
Centers for Disease Control and Prevention. U.S. selected practice recommendations for contraceptive use, 2013. MMWR. 2013;62(5):1–64.
Fritz M, Speroff L. Clinical gynecologic endocrinology and infertility. 8th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2011.
WHO. Medical eligibility criteria for contraceptive use. 4th ed. Geneva: WHO; 2009.
Neinstein LS, Gordon CM, Katzman DK, Rosen DS, Woods ER. Adolescent health care. A practical guide. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2008.
Nelson AL, Katz T. Initiation and continuation rates seen in 2-year experience with same day injections of DMPA. Contraception. 2007;75(2):84–7. Epub 2006 31 Oct.
Rickert VI, Tiezzi L, Lipshutz J, León J, Vaughan RD, Westhoff C. Depo now: preventing unintended pregnancies among adolescents and young adults. J Adolesc Health. 2007;40(1):22–8.
Manchikanti Gomez A, Grimes DA, Lopez LM; Schultz KF. Steroid hormones for contraception in women with sickle cell disease. Cochrane Database Syst Rev. 2007;(2):CD006261.
Mattson RH, Cramer JA, Darney PD, Naftolin F. Use of oral contraceptives by women with epilepsy. JAMA. 1986;256:238–40.
Mattson RH, Rebar RW. Contraceptive methods for women with neurologic disorders. Am J Obstet Gynecol. 1993;168:2027–32.
Mosher WD, Jones J. Use of contraception in the United States: 1982–2008. Vital Health Stat. 2010;23(29):1–44.
Funk S, Miller MM, Mishell Jr DR, Archer DF, Poindexter A, Schmidt J. Safety and efficacy of Implanon, a single-rod implantable contraceptive containing etonogestrel. Contraception. 2005;71(5):319–26.
Brito MB, Ferriani RA, Quintana SM, Yazlle ME, de Sá Silva MF, Vieira CS. Safety of the etonogestrel releasing implant during the immediate postpartum period: a pilot study. Contraception. 2009;80:519–26.
Lewis L, Doherty D, Hickey M, Skinner AR. Implanon as a contraceptive choice for teenage mothers: a comparison of contraceptive choices, acceptability and repeat pregnancy. Contraception. 2010;81(5):421–6.
Yisa SB, Okenwa AA, Husemeyer RP. Treatment of pelvic endometriosis with etonogestrel subdermal implant (Implanon®). J Fam Plan Reprod Health Care. 2005;31:67–9.
Guazzelli CA, de Queiroz FT, Barbieri M, Torloni MR, de Araujo FF. Etonogestrel implant in postpartum adolescents: bleeding pattern, efficacy and discontinuation rate. Contraception. 2010;82(3):256–9. Epub 2010 29 Mar.
Grimes DA, Lopez LM, O’Brien PA, Raymond EG. Progestin-only pills for contraception. Cochrane Database Syst Rev. 2010;(1):CD007541.
Darney P, Patel A, Rosen K, Shapiro L, Kaunitz A. Safety and efficacy of a single-rod etonogestrel implant (Implanon): results from 11 international clinical trials. Fertil Steril. 2009;91(5):1646–53. Epub 2008 18 Apr.
Harel Z, Biro FM, Kollar LM, Rauh JL. Adolescents’ reasons for and experience after discontinuation of the long-acting contraceptives Depo-Provera and Norplant. J Adolesc Health. 1996;19(2):118–23.
Bonny AE, Britto MT, Huang B, et al. Weight gain, adiposity, and eating behaviors among adolescent females on depot medroxyprogesterone acetate (DMPA). J Pediatr Adolesc Gynecol. 2004;17:109–15.
Le YC, Rahman M, Berenson AB. Early weight gain predicting later weight gain among depot medroxyprogesterone acetate users. Obstet Gynecol. 2009;114(2 Pt 1):279–84.
Bonny AE, Ziegler J, Harvey R, et al. Weight gain in obese and nonobese adolescent girls initiating depot medroxyprogesterone, oral contraceptive pills, or no hormonal contraceptive method. Arch Pediatr Adolesc Med. 2006;160:40–5.
Bonny AE, Secic M, Cromer B. Early weight gain related to later weight gain in adolescents on depot medroxyprogesterone acetate. Obstet Gynecol. 2011;117(4):793–7.
Risser WL, Gefter LR, Barratt MS, Risser JM. Weight change in adolescents who used hormonal contraception. J Adolesc Health. 1999;24(6):433–6.
Harel Z, Johnson CC, Gold MA, Cromer B, Peterson E, Burkman R, et al. Recovery of bone mineral density in adolescents following the use of depot medroxyprogesterone acetate contraceptive injections. Contraception. 2010;81(4):281–91. Epub 2009 14 Dec.
Cromer B. WHO-statement on hormonal contraception and bone health. Special program of research, development and research training in human reproduction (2005). J Adolesc Health. 2006;39(2):296–301.
American College of Obstetricians and Gynecologists. ACOG Committee Opinion No. 415: Depot medroxyprogesterone acetate and bone effects. Obstet Gynecol. 2008;112:727–30.
Cromer BA. Recent clinical issues related to the use of depot medroxyprogesterone acetate (Depo-Provera). Curr Opin Obstet Gynecol. 1999;11(5):467–71.
Cromwell P, Anyan W. Depot medroxyprogesterone acetate galactorrhea. J Adolesc Health. 1998;23(2):61. Reprod. 1999;14(4):976–81. doi:10.1093/humrep/14.4.976.
Romer A, Shew M, Gilliam M, Ofner S, Fortenberry JD. The effect of depo provera medroxy progesterone acetate on sexually transmitted infection acquisition. J Adolesc Health. 2012; Epub 5 June 2012.
Mansour D, Korver T, Marintcheva-Petrova M, Fraser IS. The effects of Implanon on menstrual bleeding patterns. Eur J Contracept Reprod Health Care. 2008;13(1):13–28.
Guazzelli C, Queiroz F, Barbieri M, Barreiros FA, Torloni MR, Araujo FF. Metabolic effects of contraceptive implants in adolescents. Contraception. 2011;84(4):409–12. Epub 2011 23 Mar.
Croxatto HB, Urbancsek J, Massai R, Bennink HC, Van Beek A, and the Implanon® Study Group*. A multicentre efficacy and safety study of the single contraceptive implant Implanon®. Hum Reprod. 1999;14(4):976–81. doi:10.1093/humrep/14.4.976.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media New York
About this chapter
Cite this chapter
Barral, R.L., Gold, M.A. (2014). Progestin-Only Contraception. In: Whitaker, A., Gilliam, M. (eds) Contraception for Adolescent and Young Adult Women. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6579-9_3
Download citation
DOI: https://doi.org/10.1007/978-1-4614-6579-9_3
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-6578-2
Online ISBN: 978-1-4614-6579-9
eBook Packages: MedicineMedicine (R0)