The Genetics of Pancreatic Cancer Progression
Pancreatic cancer is caused by mutations in specific cancer genes. While these cancer genes are often categorized into those that are inherited versus somatically acquired, they may also be categorized into those that occur during carcinogenesis versus those that accumulate during clonal progression. This newfound approach to understanding pancreatic cancer genetics now opens the door to understanding those events that play a role specifically in progression to metastatic disease.
KeywordsPancreatic Cancer Exomic Sequencing Primary Carcinoma Metastatic Pancreatic Cancer Pancreatic Carcinogenesis
- Ijichi H, Chytil A, Gorska AE, Aakre ME, Fujitani Y, Fujitani S et al (2006) Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev 20(22):3147–3160PubMedCrossRefGoogle Scholar