Advances in Pharmaceutical Options and Current Clinical Trials for the Treatment of Painful Diabetic Polyneuropathy

Chapter

Abstract

Painful neuropathy is a very common diabetes-related complication and is associated with significant morbidity and has a negative impact on patients’ quality of life (QOL). The pathogenesis of diabetic painful neuropathy is complex and remains unclear but involves multiple levels of the peripheral and central nervous systems (CNSs). Despite our improved understanding of the pathogenesis of this condition, there are few disease-modifying treatments. There are several agents currently in use to ameliorate and reduce the impact of pain. These treatments can be used alone or in combination, although data regarding combination therapies are rather limited. Novel therapies are currently in development, some of which are symptomatic and others based on the pathogenesis of painful neuropathy. It is important to have a holistic approach to patients with painful diabetic neuropathy (PDN) and not to focus only on pain relief but to also assess the impact on QOL. In this chapter we review the currently available treatments for PDN and future treatments that are in development and we describe our approach to the management of patients with this troublesome condition.

Keywords

Placebo Morphine Neuropathy NMDA Quercetin 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Abd A. Tahrani
    • 1
    • 2
  • Q. Altaf
    • 2
  • Martin J. Stevens
    • 1
    • 2
  1. 1.Centre of Endocrinology Diabetes and MetabolismUniversity of BirminghamBirminghamUK
  2. 2.Department of Diabetes and EndocrinologyBirmingham Heartlands HospitalBirminghamUK

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