Stress-Induced Mutagenesis in Bacteria
Under stress, high mutation rates can be advantageous because they increase the probability of generation of the adaptive mutations. Mutation rates can be modulated by changing the proportion of constitutive mutator versus non-mutator bacteria at the population level, or by inducing stress responses, which increase mutation rates transiently in individual cells. Constitutive mutator alleles are selected because they hitchhike with the adaptive mutations they generate. There are two nonexclusive hypotheses concerning the nature of selective pressure acting on the molecular mechanisms controlling stress-induced mutagenesis: stress-induced mutagenesis could be an unavoidable by-product of mechanisms involved in survival under stress, or stress-induced mutator phenotypes could be selected for in the same way as constitutive mutator alleles; that is, via hitchhiking with the adaptive mutations they generate. However, regardless of the nature of selective pressure acting on stress-induced mutagenesis, it is very likely that the resulting increased genetic variability plays an important role in the bacterial evolution.
KeywordsSugar Migration Phosphorus Codon Recombination
This work was supported by FP7-HEALTH-F3-2010-241476 and ANR-09-BLAN-0251 grants.
- Bijlsma R, Loeschcke V (eds) (1997) Environmental stress, adaptation, and evolution, vol EXS 83. Birkhäuser, BaselGoogle Scholar
- del Campo R, Morosini MI, de la Pedrosa EG, Fenoll A, Munoz-Almagro C, Maiz L, Baquero F, Canton R (2005) Population structure, antimicrobial resistance, and mutation frequencies of Streptococcus pneumoniae isolates from cystic fibrosis patients. J Clin Microbiol 43:2207–2214PubMedCrossRefGoogle Scholar
- Friedberg EC, Walker GC, Siede W, Wood RD, Schultz RA, Ellenberger T (2006) DNA repair and mutagenesis. ASM Press, Washington, DCGoogle Scholar
- Hengge-Aronis R (2000) The general stress response in Escherichia coli. In: Storz G, Hengge-Aronis R (eds) Bacterial stress responses. ASM Press, Washington DC, pp 161–178Google Scholar
- Kim SR, Maenhaut-Michel G, Yamada M, Yamamoto Y, Matsui K, Sofuni T, Nohmi T, Ohmori H (1997) Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA. Proc Natl Acad Sci USA 94:13792–13797PubMedCrossRefGoogle Scholar
- Roberts JW, Devoret R (1983) Lysogenic induction. In: Hendrix RW, Roberts JW, Stahl FW, Weisberg RA (eds) Lambda II. Cold Spring Harbor Laboratory, Cold Spring Harbor, pp 123–144Google Scholar
- Saumaa S, Tover A, Kasak L, Kivisaar M (2002) Different spectra of stationary-phase mutations in early-arising versus late-arising mutants of Pseudomonas putida: involvement of the DNA repair enzyme MutY and the stationary-phase sigma factor RpoS. J Bacteriol 184:6957–6965PubMedCrossRefGoogle Scholar
- Travis JM, Travis ER (2002) Mutator dynamics in fluctuating environments. Proceedings 269:591–597Google Scholar