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Principles of Practice

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Hormone Therapy
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Abstract

For decades, menopausal-range women have been treated as a homogenous subgroup, with HT seen as a one-size-fits-all prescription. Hormone therapy can no longer be expected to be the automatic prescription and “cure” for female aging that clinicians only a few years ago desired it to be. Today, HT and menopause management demand a focus on managing individual symptoms, paying close attention to what the patient reports, understanding the science, and helping patients demystify the many confusing popular reports they may have heard about menopause and about hormone therapies. The menopausal-range years offer a window of therapeutic opportunity, in which clinicians can help women move from their years of reproductive potential, to the postmenopausal period, with concern for symptomatic relief and general good health.

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Bibliography

  1. Bechlioulis A, Naka KK, Kalantaridou SN, et al. Increased vascular inflammation in early menopausal women is associated with hot flush severity. J Clin Endocrinol Metab. 2012;97(5):E760–4.

    Article  PubMed  CAS  Google Scholar 

  2. Collins P, Rosano G, Casey C, et al. Management of cardiovascular risk in the peri-menopausal woman: a consensus statement of European cardiologists and gynaecologists. Eur Heart J. 2007;28:2028–40.

    Article  PubMed  Google Scholar 

  3. Cumming GP, Currie HD, Panay N, et al. Stopping hormone replacement therapy: were women ill advised? Menopause Int. 2011;17:82–7.

    Article  PubMed  Google Scholar 

  4. Hisamoto K, Bender JR. Vascular cell signaling by membrane estrogen receptors. Steroids. 2005;70:382–7.

    Article  PubMed  CAS  Google Scholar 

  5. Ichikawa A, Sumino H, Ogawa T, et al. Effects of long-term transdermal hormone replacement therapy on the renin-angiotensin-aldosterone system, plasma bradykinin levels and blood pressure in normotensive postmenopausal women. Geriatr Gerontol Int. 2008;8:259–64.

    Article  PubMed  Google Scholar 

  6. Kuhl H. Mechanisms of sex steroids: future developments. Maturitas. 2004;47: 285–91.

    Article  PubMed  CAS  Google Scholar 

  7. Maki PM, Dennerstein L, Clark M. Perimenopausal use of hormone therapy is associated with enhanced memory and hippocampal function later in life. Brain Res. 2011;1379:232–43.

    Article  PubMed  CAS  Google Scholar 

  8. Mong JA, Baker FC, Mahoney MM, et al. Sleep, rhythms, and the endocrine brain: influence of sex and gonadal hormones. J Neurosci. 2011;31(45):16107–16.

    Article  PubMed  CAS  Google Scholar 

  9. Morgan ML, Cook IA, Rapkin AJ, Leuchter AF. Neurophysiologic changes during estrogen augmentation in perimenopausal depression. Maturitas. 2007;56:54–60.

    Article  PubMed  CAS  Google Scholar 

  10. Ostberg JE, Storry C, Donald AE, et al. A dose–response study of hormone replacement in young hypogonadal women: effects on intima media thickness and metabolism. Clin Endocrinol. 2007;66:557–64.

    CAS  Google Scholar 

  11. Pluchino N, Bucci F, Cela V, et al. Menopause and mental well-being: timing of symptoms and timing of hormone treatment. Womens Health (Lond Engl). 2011;7(1): 71–80.

    Article  CAS  Google Scholar 

  12. Practice Committee of the American Society for Reproductive Medicine. Estrogen and progestogen therapy in postmenopausal women. Fertil Steril. 2008;90 suppl 3: S88–102.

    Google Scholar 

  13. Archer DF. Progestogens: effects on clinical and biochemical parameters in postmenopausal women. Menopause. 2005;12(5):484–7.

    Article  PubMed  Google Scholar 

  14. Prossnitz ER, Oprea TI, Sklar LA, Arterburn JB. The ins and outs of GPR30: a transmembrane estrogen receptor. J Steroid Biochem Mol Biol. 2008;109(3–5): 350–3.

    Article  PubMed  CAS  Google Scholar 

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© 2013 Springer Science+Business Media New York

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Sherif, K. (2013). Principles of Practice. In: Hormone Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6268-2_2

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  • DOI: https://doi.org/10.1007/978-1-4614-6268-2_2

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6267-5

  • Online ISBN: 978-1-4614-6268-2

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