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Roles of Hippo Signaling During Mouse Embryogenesis

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The Hippo Signaling Pathway and Cancer

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Abstract

Embryos undergo dynamic morphological changes during embryogenesis, and elaborate the basic body plan of adults from a single fertilized egg. The Hippo signaling pathway, originally identified as a tumor suppressor signaling pathway in Drosophila, is conserved in mice and controls intercellular communication by cell–cell contacts. Recent studies of mouse mutants reveal the roles of Hippo pathway components in the various stages of embryogenesis. Hippo signaling not only regulates cell proliferation and apoptosis but also controls cell fate specification. In this review, I summarize the roles of Hippo signaling during early embryogenesis and discuss the conservation and divergence of the roles and pathways in flies and mice depending upon the developmental stages.

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Authors and Affiliations

  1. Department of Cell Fate Control, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan

    Hiroshi Sasaki

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  1. Hiroshi Sasaki
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Correspondence to Hiroshi Sasaki .

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Editors and Affiliations

  1. , Department of Molecular Cell Biology, Weizmann Institute of Science, Herzl St. 234, Rehovot, 76100, Israel

    Moshe Oren

  2. , Department of Molecular Cell Biology, Weizmann Institute of Science, Herzl St. 234, Rehovot, 76100, Israel

    Yael Aylon

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Sasaki, H. (2013). Roles of Hippo Signaling During Mouse Embryogenesis. In: Oren, M., Aylon, Y. (eds) The Hippo Signaling Pathway and Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6220-0_12

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