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Hippo in Cell Cycle and Mitosis

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The Hippo Signaling Pathway and Cancer

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Abstract

The Hippo pathway regulates cell growth and cell cycle-dependent ­processes, including mitosis, cell cycle checkpoints, mitotic checkpoints, and DNA damage response (DDR) checkpoints, thereby preventing the accumulation of abnormal cells with aneuploidy and polyploidy. Moreover, Mst1/2, Lats1/2, Mob1, and Rassf1A ­primarily colocalize with mitotic regulators, such as Aurora A and Polo, at the centrosome, and then dynamically translocate to the nucleus or the central spindle and the midbody in response to various stimuli. In particular, Lats1/2 play various roles in the DDR checkpoint, maintaining centrosome integrity, mitotic checkpoints (including the spindle assembly checkpoint (SAC)), mitotic exit, cytokinesis, EMT, and cellular senescence. Lats2 also plays a pivotal role in the cell cycle checkpoint via the p53 pathway, thereby functioning as another “guardian” of genome integrity. Therefore, the machinery and related molecules within the Hippo pathway may be potent and promising cancer therapy targets, which may arrest or kill malignant tumor cells without the side effects associated with commonly used treatments.

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Acknowledgements

We thank Dr. Moshe Oren and Dr. Yael Aylon for inviting us to write this review. We also thank Dr. Patrick Hughes and Dr. Stephen Cooke (Bioedit Ltd.) for critically reading the manuscript.

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Authors and Affiliations

  1. Department of Molecular Genetics, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita City, Osaka, 565-0871, Japan

    Norikazu Yabuta & Hiroshi Nojima

  2. DNA-chip Development Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita City, Osaka, 565-0871, Japan

    Hiroshi Nojima

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  1. Norikazu Yabuta
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Correspondence to Hiroshi Nojima .

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  1. , Department of Molecular Cell Biology, Weizmann Institute of Science, Herzl St. 234, Rehovot, 76100, Israel

    Moshe Oren

  2. , Department of Molecular Cell Biology, Weizmann Institute of Science, Herzl St. 234, Rehovot, 76100, Israel

    Yael Aylon

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Yabuta, N., Nojima, H. (2013). Hippo in Cell Cycle and Mitosis. In: Oren, M., Aylon, Y. (eds) The Hippo Signaling Pathway and Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6220-0_10

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