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Neuroanatomy of the Kisspeptin Signaling System in Mammals: Comparative and Developmental Aspects

  • Michael N. Lehman
  • Stanley M. Hileman
  • Robert L. Goodman
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 784)

Abstract

Our understanding of kisspeptin and its actions depends, in part, on a detailed knowledge of the neuroanatomy of the kisspeptin signaling system in the brain. In this chapter, we will review our current knowledge of the distribution of kisspeptin cells, fibers, and receptors in the mammalian brain, including the development, phenotype, and projections of different kisspeptin subpopulations. A fairly consistent picture emerges from this analysis. There are two major groups of kisspeptin cell bodies: a large number in the arcuate nucleus (ARC) and a smaller collection in the rostral periventricular area of the third ventricle (RP3V) of rodents and preoptic area (POA) of non-rodents. Both sets of neurons project to GnRH cell bodies, which contain Kiss1r, and the ARC kisspeptin population also projects to GnRH axons in the median eminence. ARC kisspeptin neurons contain neurokinin B and dynorphin, while a variable percentage of those cells in the RP3V of rodents contain galanin and/or dopamine. Neurokinin B and dynorphin have been postulated to contribute to the control of GnRH pulses and sex steroid negative feedback, while the role of galanin and dopamine in rostral kisspeptin neurons is not entirely clear. Kisspeptin neurons, fibers, and Kiss1r are found in other areas, including widespread areas outside the hypothalamus, but their physiological role(s) in these regions remains to be determined.

Keywords

Median Eminence GnRH Neuron Preoptic Region Kiss1 mRNA Kiss1 Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

We thank Dr. Lique M. Coolen for her valuable assistance in the preparation of Fig. 3.3. This work is supported by a grant from NIH (NIH RO1 HD033916)

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Michael N. Lehman
    • 1
  • Stanley M. Hileman
    • 2
  • Robert L. Goodman
    • 2
  1. 1.Department of Neurobiology and Anatomical SciencesUniversity of Mississippi Medical CenterJacksonUSA
  2. 2.Department of Physiology and PharmacologyWest Virginia University School of MedicineMorgantownUSA

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