Glucagonoma is a rare tumor of alpha cells in the pancreas. This disease results in glucagon overproduction of approximately 1,000 times normal. The incidence of this pathology is thought to be 1 in 20 million, although this is likely an underestimation given the lack of specific symptoms. The effect on long-term survival is not known because of the rarity of the condition. Although it originates in the pancreas, the effects of this disease are widespread and can affect multiple organ systems.
Clinical signs and findings include:
This is associated with a glucagonoma syndrome with the following clinical findings:
Weight loss (80 %)
Neuroendocrine Tumor Glucose Intolerance Multiple Endocrine Neoplasia Alpha Cell Multiple Organ System
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.
Simon P, Spilcke-Liss E, Wallaschofski H. Endocrine tumors of the pancreas. Endocrinol Metab Clin North Am. 2006;35:431–47.PubMedCrossRefGoogle Scholar
Guirado AG, Sanchez-Fayos P, Bosch O, et al. Endoscopic findings of a pancreatic glucagonoma. Dig Dis Sci. 2001;46:2779–82.PubMedCrossRefGoogle Scholar
Kindmark H, Sundin A, Granberg D, et al. Endocrine pancreatic tumors with glucagon hypersecretion: a retrospective study of 23 cases during 20 years. Med Oncol. 2007;24:330–7.PubMedCrossRefGoogle Scholar