Glucagonoma: Gastrointestinal Features



Glucagonoma is a rare tumor of alpha cells in the pancreas. This disease results in glucagon overproduction of approximately 1,000 times normal. The incidence of this pathology is thought to be 1 in 20 million, although this is likely an underestimation given the lack of specific symptoms. The effect on long-term survival is not known because of the rarity of the condition. Although it originates in the pancreas, the effects of this disease are widespread and can affect multiple organ systems.

Clinical signs and findings include:

This is associated with a glucagonoma syndrome with the following clinical findings:

Weight loss (80 %)


Neuroendocrine Tumor Glucose Intolerance Multiple Endocrine Neoplasia Alpha Cell Multiple Organ System 
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Internal MedicineUniversity of Connecticut Health CenterFarmingtonUSA

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