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Pseudoxanthoma Elasticum: Dermatological Features

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Abstract

Clinical sign and symptoms include:

Genetic disease in which elastic fibers become calcified and weak demonstrating skin manifestations in the second or third decade (but occasionally in childhood); serious ocular and vascular complications manifest in the third or fourth decade of life

Cutaneous lesions start as small (1–5 mm) yellowish papules in a reticular pattern at flexural areas (including the neck and axilla) associated with cutaneous laxity

Cutaneous lesions coalesce into larger plaques of inelastic, leathery skin with a yellow hue; skin has a plucked chicken/cobblestone appearance

Also can have perforating pseudoxanthoma elasticum with calcified elastic fibers extruding from the skin; clinically, these lesions appear as keratotic papules

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References

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Author information

Authors and Affiliations

  1. Yale Department of Internal Medicine, Yale New Haven Hospital, 20 Yale Street, New Haven, CT, 06510, USA

    Liam Zakko

  2. Department of Dermatology, University of Connecticut Health Center, 21 South Road, Farmington, CT, 06030, USA

    Justin Finch, Marti J. Rothe & Jane M. Grant-Kels

Authors
  1. Liam Zakko
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  2. Justin Finch
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  3. Marti J. Rothe
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  4. Jane M. Grant-Kels
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Corresponding author

Correspondence to Liam Zakko .

Editor information

Editors and Affiliations

  1. Department of Medicine, Gastroenterology Division,, University of Connecticut Health Center, 263 Farmington Ave., Farmington, 06030, Connecticut, USA

    George Y. Wu

  2. , Department of Medicine, University of Connecticut, 56 Kingswood Road, West Hartford, 06119, Connecticut, USA

    Nathan Selsky

  3. , Univ. of CT Health Ctr, Dermatol. Dept., University of Connecticut, 21 South Road, Farmington, 06032, Connecticut, USA

    Jane M. Grant-Kels

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Zakko, L., Finch, J., Rothe, M.J., Grant-Kels, J.M. (2013). Pseudoxanthoma Elasticum: Dermatological Features. In: Wu, G., Selsky, N., Grant-Kels, J. (eds) Atlas of Dermatological Manifestations of Gastrointestinal Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6191-3_28

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  • DOI: https://doi.org/10.1007/978-1-4614-6191-3_28

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6190-6

  • Online ISBN: 978-1-4614-6191-3

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