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Conductive Polymer-Based Materials for Medical Electroanalytic Applications

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Applications of Electrochemistry in Medicine

Part of the book series: Modern Aspects of Electrochemistry ((MAOE,volume 56))

Abstract

Since the discovery of high electrical conductivity in doped polyacetylene in 1977 [1], the investigations in the field of conducting polymers (CPs) have expanded rapidly in number, scope of research, and importance. The 2000 Nobel Prize in Chemistry was awarded to A. J. Heeger, A. McDiarmid, and H. Shirakawa for the discovery and development of electrically conductive polymers. The choice of the Nobel Committee was motivated by the important scientific position that the field has achieved and the consequences in terms of practical applications and of interdisciplinary development between chemistry and physics [2]. In the last decade the field of CPs and various CP-based materials has advanced further into new areas of research and technological developments. One of these intensively progressing areas is the involvement of CP-based materials in electrocatalytical applications, with a strong emphasis set on chemical and biochemical sensing. The electroanalytical response of CPs and CP-based composites was studied for a great number of compounds that are involved in the human metabolism, present medications, or harmful chemicals for humans. The large amount of publications on medical electroanalytical applications of CP-based materials are scattered over a number of specialized journals with main scopes in electroanalytical and analytical chemistry, sensing and biosensing, polymer science, medical studies, etc. Due to the highly spread and abundant literature it is nowadays difficult to get a general idea in this specific field of research. The present chapter attempts to outline the state of the art and hopefully to provoke further effort in this challenging scientific area with practical importance for medical diagnostics and medical treatments.

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Abbreviations

AA:

Ascorbic acid

ABSA:

Aminobenzenesulfonic acid

CA:

Chronoamperometry

CP:

Conducting polymers

CPE:

Carbon paste electrode

CNT:

Carbon nanotubes

CV:

Cyclic voltammetry

DA:

Dopamine

DPV:

Differential pulse voltammetry

EPI:

Epinephrine

FIA:

Flow injection analysis

LbL:

Layer-by-layer

LOD:

Limit of detection

MIP:

Molecularly imprented polymer

MSE:

Mercury sulfate electrode

MWCNT:

Multiwalled carbon nanotubes

NAD+ :

Nicotinamide adenine dinucleotide

NOREPI:

Norepinephrine

NPs:

Nanoparticles

P3MT:

Poly(3-methylthiophene)

PAA:

Polyacrilic acid

PAMPSA:

Poly(2-acryalamido-2-methyl-1-propane-sulfonic acid)

PANI:

Polyaniline

PEDOT:

Poly(3,4-ethylenedioxythiophene)

POMA:

Poly(o-methoxyaniline)

PPY:

Polypyrrole

PSS:

Polysterenesulfonate

PTHI:

Polythiophene

PVS:

Polyvinylsulfonate

RDE:

Rotating disc electrode

SCE:

Standard calomel electrode

SDS:

Sodium dodecylsulfate

SHE:

Standard hydrogen electrode

SWCNT:

Single-walled carbon nanotubes

SWV:

Square wave voltammetry

UA:

Uric acid

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Acknowledgments

Financial support of project DTK 02/25 with National Science Fund of Bulgaria is gratefully acknowledged.

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    Vessela Tsakova

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    Mordechay Schlesinger

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Tsakova, V. (2013). Conductive Polymer-Based Materials for Medical Electroanalytic Applications. In: Schlesinger, M. (eds) Applications of Electrochemistry in Medicine. Modern Aspects of Electrochemistry, vol 56. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-6148-7_8

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