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Taurine 8 pp 427-435 | Cite as

Synergistic Effects of Taurine and l-Arginine on Attenuating Insulin Resistance Hypertension

  • Ying Feng
  • Jitao Li
  • Jiancheng Yang
  • Qunhui Yang
  • Qiufeng Lv
  • Yongchao Gao
  • Jianmin Hu
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 775)

Abstract

To elucidate the synergistic effects of taurine and l-arginine on hypertension, 25% fructose were administered to male Wistar rats for 3 months to establish insulin resistance hypertensive models. Rats with the systolic blood pressure (SBP) higher than 150 mmHg were considered as model rats. Forty-two model rats were randomly divided into six groups and administered with 3% taurine, 2.7% taurine + 0.3% l-arginine, 2.1% taurine + 0.9% l-arginine, 1.5% taurine + 1.5% l-arginine and 3% l-arginine in drinking water respectively. The results showed that coadministration of taurine (1.5%) and l-arginine (1.5%) could bring the levels of SBP, blood glucose, and insulin down to normal levels after 4 weeks. The thickness of blood vessels increased significantly in model group, which could be reversed by taurine and l-arginine. Serum NO, cGMP, and ET levels could return to normal levels. These data indicated that both taurine and l-arginine could ameliorate vascular remodeling and showed obvious antihypertensive effects, and taurine (1.5%) and l-arginine (1.5%) in the drinking water showed a better result in the cure of hypertension.

Keywords

Systolic Blood Pressure Model Group Antihypertensive Effect cGMP Level Taurine Supplementation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

SBP

Systolic blood pressure

Ins

Insulin

ET

Endothelin

cGMP

Cyclic guanosine monophosphate

References

  1. Anuradha CV, Balakrishnan SD (1999) Taurine attenuates hypertension and improves insulin sensitivity in the fructose-fed rat, an animal model of insulin resistance. Can J Physiol Pharmacol 77:749–754PubMedCrossRefGoogle Scholar
  2. Gokce N (2004) L-arginine and hypertension. J Nutr 134(10 Suppl):2807S–2811S, discussion 2818S-2819SPubMedGoogle Scholar
  3. Harada H, Tsujino T, Watari Y, Nonaka H, Emoto N, Yokoyama M (2004) Oral taurine supplementation prevents fructose-induced hypertension in rats. Heart Vessels 19(3):132–136PubMedCrossRefGoogle Scholar
  4. Hagar HH, El Etter E, Arafa M (2006) Taurine attenuates hypertension and renal dysfunction induced by cyclosporine A in rats. Clin Exp Pharmacol Physiol 33(3):189–196PubMedCrossRefGoogle Scholar
  5. Hu J, Xu X, Yang J, Wu G, Sun C, Lv Q (2009) Antihypertensive effect of taurine in rat. Adv Exp Med Biol 643:75–84PubMedCrossRefGoogle Scholar
  6. Kapakos G, Bouallegue A, Daou GB, Srivastava AK (2010) Modulatory role of nitric oxide/cGMP System in endothelin-1-induced signaling responses in vascular smooth muscle cells. Curr Cardiol Rev 6(4):247–254PubMedCrossRefGoogle Scholar
  7. Militante JD, Lombardini JB (2002) Treatment of hypertension with oral taurine: experimental and clinical studies. Amino Acids 23(4):381–393PubMedCrossRefGoogle Scholar
  8. Nakaya Y, Minami A, Harada N et al (2000) Taurine improves insulin sensitivity in the Otsuka Long-Evans Tokushima fatty rat, a model of spontaneous type 2 diabetes. Am J Clin Nutr 71:54–58PubMedGoogle Scholar
  9. Rahman MM, Park HM, Kim SJ, Go HK, Kim GB, Hong CU, Lee YU, Kim SZ, Kim JS, Kang HS (2011) Taurine prevents hypertension and increases exercise capacity in rats with fructose-induced hypertension. Am J Hypertens 24(5):574–581PubMedCrossRefGoogle Scholar
  10. Siani A, Pagano E, Iacone R et al (2000) Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 13:547–551PubMedCrossRefGoogle Scholar
  11. Wascher TC, Graier WF, Dittrich P et al (1997) Effects of low-dose L-arginine on insulin mediated vasodilatation and insulin sensitivity. Eur J Clin Invest 27:690–695PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Ying Feng
    • 1
  • Jitao Li
    • 1
  • Jiancheng Yang
    • 1
  • Qunhui Yang
    • 1
  • Qiufeng Lv
    • 1
  • Yongchao Gao
    • 1
  • Jianmin Hu
    • 1
  1. 1.College of Animal Science & Veterinary MedicineShenyang Agricultural UniversityShenyangP.R. China

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