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Taurine 8 pp 287-297 | Cite as

Inhibitory Effects of Taurine on STZ-Induced Apoptosis of Pancreatic Islet Cells

  • Shumei Lin
  • Jiancheng Yang
  • Gaofeng Wu
  • Mei Liu
  • Qiufeng Lv
  • Qunhui Yang
  • Jianmin Hu
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 775)

Abstract

The present research aims to investigate the inhibition effect of taurine on the apoptosis of pancreatic islet cells induced by Streptozotocin (STZ). One hundred male Wistar rats weighing 180–200 g were randomly divided into two groups, rats in the experimental were intraperitoneally injected with 2% STZ (50 mg/kg bw, dissolved in 0.1 mmol/L pH 4.2 citrate buffer), rats in the control group were injected with the same volume of citrate buffer. Rats with the fasting blood glucose level higher than 16.7 mmol/L were selected and randomly divided into four groups: Rats in M group were STZ-induced diabetes rats, rats in T1, T2, and T3 groups were intragastrically administered with taurine (dissolved in 0.5% sodium carboxymethyl cellulose as thickening agent) once a day for 4 weeks with the contents of 0.6 g/kg, 1.2 g/kg, and 2.4 g/kg bw, respectively, while rats in group C and M were given the same amount of thickening agent as T2 group. Four weeks later, pancreatic tissues were fixed and processed for paraffin section. The results showed that STZ induced a significant increase in apoptotic rate of pancreatic islet cells, up-regulated the expression of bax and Fas and down-regulated the expression of Bcl-2, which were significantly blocked by taurine (P < 0.05). The results indicated that taurine could significantly restrain apoptosis of pancreatic islet cells induced by STZ.

Keywords

Islet Cell Integral Optical Density Pancreatic Islet Cell Taurine Supplementation Pancreatic Gland 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

T

Taurine

STZ

Streptozotocin

Notes

Acknowledgments

Financial support from the National Research Foundation of China (Project no. 30972154) and Doctoral initiaitng project of liaoning province (Project no. 20111083) is acknowledged.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Shumei Lin
    • 1
  • Jiancheng Yang
    • 1
  • Gaofeng Wu
    • 1
  • Mei Liu
    • 1
  • Qiufeng Lv
    • 1
  • Qunhui Yang
    • 1
  • Jianmin Hu
    • 1
  1. 1.College of Animal Science & Veterinary MedicineShenyang Agricultural UniversityShenyangP.R. China

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