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Multiple Organ Failure

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Abstract

While traumatic brain injury and uncontrolled hemorrhage remain the leading causes of death after trauma, sepsis followed by multiple organ failure (MOF) are leading contributors to mortality in critically ill surgical and trauma patients. MOF is the leading cause of morbidity in the intensive care unit (ICU) following trauma and represents the endpoint of the spectrum of SIRS and sepsis [1]. Despite the identification of this disease process in the early 1970s, our understanding of the pathophysiology and the ensuing treatment of this syndrome remains a perplexing entity to which entire books have been dedicated. This chapter provides a brief overview of the evolution of the disease, the clinical presentation, and discusses the epidemiology and salient pathophysiology, as well as current treatment options and future considerations of this disease.

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Authors and Affiliations

  1. Department of Trauma, Acute Care Surgery and Surgical Critical Care, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L-611, Portland, OR, 97239, USA

    Stephanie Gordy M.D., F.A.C.S.

  2. Oregon Health and Science University, Portland, USA

    Martin A. Schreiber M.D., F.A.C.S. (Professor of Surgery, Chief of Trauma Surgery)

Authors
  1. Stephanie Gordy M.D., F.A.C.S.
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  2. Martin A. Schreiber M.D., F.A.C.S.
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Correspondence to Stephanie Gordy M.D., F.A.C.S. .

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Editors and Affiliations

  1. Science Center, Department of Surgery, The University of Texas Health, 6431 Fannin Street, MSB 4.292, Houston, 77030, Texas, USA

    Laura J. Moore

  2. The Methodist Hospital, Department of Surgery, Weill Cornell Medical College, 6550 Fannin St, SM 1661A, Houston, 77030, Texas, USA

    Krista L. Turner

  3. School of Medicine, Department of Surgery, New York University, 550 First Avenue, New Bellevue 15 East 9, New York, 10016, New York, USA

    S. Rob Todd

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Gordy, S., Schreiber, M.A. (2013). Multiple Organ Failure. In: Moore, L., Turner, K., Todd, S. (eds) Common Problems in Acute Care Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6123-4_7

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