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Acute Renal Insufficiency (Failure)

  • Chang-I Wu
  • Vasiliy Sim
  • S. Rob Todd
Chapter

Abstract

One of the primary roles of the kidneys is to filter waste material from the blood. The inability of the kidneys to do this leads to renal failure. Acute renal insufficiency (ARI) is defined as the sudden onset (<48 h) of impaired kidney function. This is represented by a rise in the serum creatinine or a decrease in the urine output. The serum creatinine serves as a useful biomarker for measuring the flow rate of fluids through the kidneys, termed the glomerular filtration rate (GFR). As the clearance of creatinine and GFR decrease, the serum creatinine correspondingly increases signifying impaired renal function. The most common formula used to estimate GFR is the Cockcroft–Gault formula:
$$ \mathrm{GF}{{\mathrm{R}}_{\mathrm{CG}}}=\frac{{\left( {140-\mathrm{Age}} \right)\times \mathrm{Weight}\ \left( {\mathrm{kg}} \right)}}{{72\times \mathrm{Serum}\ \mathrm{creatinine}\ \left( {\mathrm{mg}/\mathrm{dL}} \right)}}\times [0.85\ \mathrm{if}\ \mathrm{Female}] $$
$$ \frac{{\left[ {\left( {140-\mathrm{Age}} \right) \times \mathrm{Mass}\left( {\mathrm{in}\ \mathrm{kg}} \right)} \right]}}{{\left[ {72 \times \mathrm{Serum}\ \mathrm{creatinine}\left( {\mathrm{in}\ \mathrm{mg}/\mathrm{dL}} \right)} \right]}} $$

Keywords

Renal Replacement Therapy Continuous Renal Replacement Therapy Hepatorenal Syndrome Rifle Criterion Acute Renal Insufficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Columbia University Mailman School of Public HealthNew YorkUSA
  2. 2.Department of SurgeryBrookdale University Hospital and Medical CenterBrooklynUSA
  3. 3.Division of Trauma, Emergency Surgery, and Surgical Critical Care, Department of SurgeryNew York University Langone Medical CenterNew YorkUSA

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