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CD1a, CD1b, and CD1c in Immunity Against Mycobacteria

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The New Paradigm of Immunity to Tuberculosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 783))

Abstract

The CD1 system is composed of five types of human CD1 proteins, CD1a, CD1b, CD1c, CD1d, and CD1e, and their mammalian orthologs. Each type of CD1 protein has a distinct antigen binding groove and shows differing patterns of expression within cells and in different tissues. Here we review the molecular mechanisms by which CD1a, CD1b, and CD1c capture distinct classes of self- and mycobacterial antigens. We discuss how CD1-restricted T cells participate in the immune response, emphasizing new evidence for mycobacterial recognition in vivo in human and non-human models.

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Authors and Affiliations

  1. Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Ildiko Van Rhijn, Dalam Ly & D. Branch Moody

  2. Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

    Ildiko Van Rhijn

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  1. Ildiko Van Rhijn
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  2. Dalam Ly
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Correspondence to Ildiko Van Rhijn or D. Branch Moody .

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  1. McGill University, Montreal, H2X 2P2, Québec, Canada

    Maziar Divangahi

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Van Rhijn, I., Ly, D., Moody, D.B. (2013). CD1a, CD1b, and CD1c in Immunity Against Mycobacteria. In: Divangahi, M. (eds) The New Paradigm of Immunity to Tuberculosis. Advances in Experimental Medicine and Biology, vol 783. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6111-1_10

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