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Taurine 8 pp 347–355Cite as

Taurine Enhances the Sexual Response and Mating Ability in Aged Male Rats

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 776)

Abstract

It has been demonstrated that taurine is abundant in male reproductive organs, and can be biosynthesized by testis, but the taurine concentration will reduce with aging. The levels of serum LH, T, NOS, and NO were found to be obviously increased by taurine supplementation in aged rats in our previous study. In addition, aging will result in a significant decline in sexual response and function, which may be attributed to the androgen deficiency. Furthermore, NO has been proposed as a crucial mediator of penile erection. That makes us hypothesize that there is potential relationship between taurine decline and erection dysfunction in aged males. So the primary aim of the present study was to investigate the effect of taurine on male sexuality in rats. Taurine was offered in water to male aged (20 months old) rats for 110 days. The effects of taurine on the sexual response, mating ability, levels of serum reproductive hormones, and penile NOS and NO levels were investigated. The results showed that taurine can significantly reduce the EL and ML; obviously increase the ERF, MF, IF, and EJF; stimulate the secretion of GnRH, LH, and T; and elevate penis NOS and NO level in aged rats. The results indicated that taurine can enhance the sexual response and mating ability in aged male rats by increasing the level of testosterone and NO, but the exact mechanism of which needs to be further investigated.

Keywords

  • Nitric Oxide
  • Luteinizing Hormone
  • Sexual Response
  • Penile Erection
  • Taurine Supplement

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • DOI: 10.1007/978-1-4614-6093-0_32
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Abbreviations

LH:

Luteinizing hormone

T:

Testosterone

NOS:

Nitric oxide synthase

NO:

Nitric oxide

Con:

Control group

Tau:

Taurine group

β-Ala:

β-Alanine group

EL:

Erection latency

ERF:

Erection frequency

ML:

Mount latency

MF:

Mount frequency

IF:

Intromission frequency

EJF:

Ejaculation frequency

GnRH:

Gonadotropin-releasing hormone

FSH:

Follicle-stimulating hormone

E2:

Estradiol

LH:

Luteinizing hormone

TP:

Total protein

References

  • Alvarez JG, Storey BT (1983) Taurine, hypotaurine, epinephrine and albumin inhibit lipid peroxidation in rabbit spermatozoa and protect against loss of motility. Biol Reprod 29:548–555

    PubMed  CrossRef  CAS  Google Scholar 

  • Andersson KE, Wagner G (1997) Physiology of penile erection. Physiol Rev 75:191–236

    Google Scholar 

  • Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH (1992) Nitric oxide: a physiologic mediator of penile erection. Science 257(5068):401–403

    PubMed  CrossRef  CAS  Google Scholar 

  • Dawson R Jr, Wallace DR (1992) Taurine content in tissues from aged Fisher 344 rats. Age 15:73–81

    CrossRef  CAS  Google Scholar 

  • Fraser LR (1986) Both taurine and albumin support mouse sperm motility and fertilizing ability in vitro but there is no obligatory requirement for taurine. J Reprod Fertil 77:271–280

    PubMed  CrossRef  CAS  Google Scholar 

  • Holmes RP, Goodman HO, Shihabi ZK, Jarrow JP (1992) The taurine and hypotaurine content of human semen. J Androl 13:289–292

    PubMed  CAS  Google Scholar 

  • Hu JM, Ikemura R, Chang KT, Suzuki M, Nishihara M, Takahashi M (2000) Expression of cysteine sulfinate decarboxylase mRNA in rat mammary gland. J Vet Med Sci 62(8):829–834

    PubMed  CrossRef  CAS  Google Scholar 

  • Huxtable RJ (1992) Physiological actions of taurine. Physiol Rev 72(1):101–163

    PubMed  CAS  Google Scholar 

  • Lamberts SWJ, van den Beld AW, van der Lely AJ (1997) The endocrinology of aging. Science 278:419–424

    PubMed  CrossRef  CAS  Google Scholar 

  • Li JH, Ling YQ, Fan JJ, Zhang XP, Cui S (2006) Expression of cysteine sulfinate decarboxylase (CSD) in male reproductive organs of mice. Histochem Cell Biol 125:607–613

    PubMed  CrossRef  CAS  Google Scholar 

  • Lobo MVT, Alonso FJM, del Rio RM (2000) Immunohistochemical localization of taurine in the male reproductive organs of the rat. J Histochem Cytochem 48:313–320

    PubMed  CrossRef  CAS  Google Scholar 

  • Lugg J, Rafjer J, Gonzales-Cadavit NF (1995) Dihydrotestosterone is the active androgen in the maintenance of nitric-oxide mediated penile erection in the rat. Endocrinology 136:1495–1501

    PubMed  CrossRef  CAS  Google Scholar 

  • Lumley LA, Hull EM (1999) Effects of a D1antagonist and of sexual experience on copulation-induced Fos-like immunoreactivity in the medial preoptic nucleus. Brain Res 829(1–2):55–68

    PubMed  CrossRef  CAS  Google Scholar 

  • Meacham RB, Murray MJ (1994) Reproductive function in the aging male. Urol Clin North Am 21:549–556

    PubMed  CAS  Google Scholar 

  • Meizel S (1985) Molecules that initiate or help stimulate the acrosome reaction by their interaction with the mammalian sperm surface. Am J Anat 174(3):285–302

    PubMed  CrossRef  CAS  Google Scholar 

  • Meizel S, Lui CW, Working PK, Mrsny RJ (1980) Taurine and hypotaurine: their effects on motility, capacitation and the acrosome reaction of hamster sperm in vitro and their presence in sperm and reproductive tract fluids of several mammals. Dev Growth Differ 22(3):483–494

    CrossRef  CAS  Google Scholar 

  • Mills TM, Reilly CM, Lewis RW (1996) Androgens and penile erection: a review. J Androl 17:633–638

    PubMed  CAS  Google Scholar 

  • Mrsny RJ, Meizel S (1985) Inhibition of hamster sperm Na+, K+-ATPase activity by taurine and hypotaurine. Life Sci 36(3):271–275

    PubMed  CrossRef  CAS  Google Scholar 

  • Mulliqan T, Schmitt B (1993) Testosterone for erectile failure. J Gen Intern Med 8(9):517–521

    CrossRef  Google Scholar 

  • Oertel WH, Schmechel DE, Weise VK, Ransom DH, Tappaz ML, Krutzsch HC, Kopin IJ (1981) Comparison of cysteine sulphinic acid decarboxylase isoenzymes and glutamic acid decarboxylase in rat liver and brain. Neuroscience 6:2701–2714

    PubMed  CrossRef  CAS  Google Scholar 

  • Pasantes-Morales H, Lopez-colome AM, Salceda R, Mandel P (1976) Cysteine sulphinate decarboxylase in chick and rat retina during development. J Neurochem 27:1103–1106

    PubMed  CrossRef  CAS  Google Scholar 

  • Reilly CM, Zamorano P, Stopper VS, Mills TM (1997) Androgenic regulation of NO availability in rat penile erection. J Androl 18(2):110–115

    PubMed  CAS  Google Scholar 

  • Sachs BD, Akasofu K, McEldowney SS (1994) Effects of copulation on apomorphine-induced erection in rats. Pharmacol Biochem Behav 48(2):423–428

    PubMed  CrossRef  CAS  Google Scholar 

  • Schiavi RC, Rehman J (1995) Sexuality and aging. Urol Clin North Am 22:711–726

    PubMed  CAS  Google Scholar 

  • Swerdloff RS, Wang C (1993) Androgen deficiency and aging in men. West J Med 159:579–585

    PubMed  CAS  Google Scholar 

  • Tenover JL (1997) Testosterone and the aging male. J Androl 18:103–106

    PubMed  CAS  Google Scholar 

  • Wallace DR, Dawson JR (1990) Decreased plasma taurine in aged rats. Gerontology 36(1):19–27

    PubMed  CrossRef  CAS  Google Scholar 

  • Yang JC, Wu GF, Feng Y, Lv QF, Lin SM, Hu JM (2010a) Effects of taurine on male reproduction in rats of different ages. J Biomed Sci 17(Suppl 1):1–8, S9

    Google Scholar 

  • Yang JC,Wu GF, Feng Y, Sun CM, Lin SM, Hu JM (2010b) CSD mRNA expression in rat testis and the effect of taurine on testosterone secretion. Amino Acids 39(1):155–160

    Google Scholar 

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant No. 31001042), the Doctor Initial Foundation of Liaoning Province (Grant No. 20081065), and the Program for Shenyang Agricultural University Excellent Talents.

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Correspondence to Jianmin Hu .

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Yang, J., Lin, S., Feng, Y., Wu, G., Hu, J. (2013). Taurine Enhances the Sexual Response and Mating Ability in Aged Male Rats. In: El Idrissi, A., L'Amoreaux, W. (eds) Taurine 8. Advances in Experimental Medicine and Biology, vol 776. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6093-0_32

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