Skip to main content

Managing Real and Perceived Risks: Animal Antibiotics and Drug-Resistant Infections

  • Chapter
  • First Online:
Book cover Improving Risk Analysis

Part of the book series: International Series in Operations Research & Management Science ((ISOR,volume 185))

  • 2094 Accesses

Abstract

Many known or suspected health hazards awaken uneasiness as soon as they are mentioned, before any quantitative risk analysis is offered. Chemicals that might cause cancer or birth defects, hidden contaminants spreading in food or water or air, and invisible but possibly deadly radiation are among the hazards that directly engage our emotions. They may stir revulsion, outrage, and an impetus toward action, even if the sizes of the health risks that they create are unknown. Public concern about such threats can be amplified by news stories that present vivid anecdotes and plausible-sounding (even if unproved) conjectures about cause and effect, as well as by deliberate political, scientific, or corporate fear-mongering designed to galvanize particular actions or further particular agendas (Gardner 2009). Quantitative risk analysis (QRA) of the frequencies and severities of adverse effects caused by these hazards may have relatively little influence on the outcomes of such emotionally charged proceedings. And yet, QRA information is essential for deciding how to allocate limited social attention and resources most effectively to obtain substantial reductions in harm to human health.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Adams SJ, Cunliffe WJ, Cooke EM (1985) Long-term antibiotic therapy for acne vulgaris: effects on the bowel flora of patients and their relatives. J Invest Dermatol 85:35–37, http://www.nature.com/jid/journal/v85/n1/pdf/5614576a.pdf

    Article  Google Scholar 

  • AHFS (2008) AHFS consumer medication information. American Society of Health System Pharmacists. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?log$=drug_bottom_one&rid=med­master.chapter.a682098

  • Akwar HT, Poppe C, Wilson J, Reid-Smith RJ, Dyck M, Waddington J, Shang D, McEwen SA (2008) Associations of antimicrobial uses with antimicrobial resistance of fecal Escherichia coli from pigs on 47 farrow-to-finish farms in Ontario and British Columbia. Can J Vet Res 72(2):202–210

    Google Scholar 

  • Alban L, Nielsen EO, Dahl J (2008) A human health risk assessment for macrolide-resistant Campylobacter associated with the use of macrolides in Danish pig production. Prev Vet Med 83(2):115–129

    Article  Google Scholar 

  • Aldeyab MA, Monnet DL, López-Lozano JM, Hughes CM, Scott MG, Kearney MP, Magee FA, McElnay JC (2008) Modelling the impact of antibiotic use and infection control practices on the incidence of hospital-acquired methicillin-resistant Staphylococcus aureus: a time-series analysis. J Antimicrob Chemother 62(3):593–600

    Article  Google Scholar 

  • American Academy of Periodontology (2001) Treatment of plaque-induced gingivitis, chronic periodontitis, and other Clinical conditions. J Periodontol 72:1790–1800

    Article  Google Scholar 

  • Angulo FJ, Nargund VN, Chiller TC (2004) Evidence of an association between use of anti-microbial agents in food animals and anti-microbial resistance among bacteria isolated from humans and the human health consequences of such resistance. J Vet Med B Infect Dis Vet Public Health 51(8–9):374–379

    Article  Google Scholar 

  • Arsenault J, Letellier A, Quessy S, Morin JP, Boulianne M (2007) Prevalence and risk factors for Salmonella and Campylobacter spp. carcass contamination in turkeys slaughtered in Quebec, Canada. J Food Prot 70(6):1350–1359

    Google Scholar 

  • Barza M, Travers K (2002) Excess infections due to antimicrobial resistance: the “Attributable Fraction”. Clin Infect Dis 34(Suppl 3):S126–S130

    Article  Google Scholar 

  • Beck J, Offenbacher S (2003) Potential public health implications periodontal disease and cardiovascular disease. In: Proceeding of the public health implications of chronic periodontal infections in adults conference, Atlanta, 8–9 April 2003. http://www.cdc.gov/ORALHEALTH/publications/library/conferences/periodontal_infections08.htm

  • Beilby J, Marley J, Walker D, Chamberlain N, Burke M, FIESTA Study Group (2002) Effect of changes in antibiotic prescribing on patient outcomes in a community setting: a natural experiment in Australia. Clin Infect Dis 34(1):55–64

    Article  Google Scholar 

  • Bell DM, Kozarsky PE, Stephens DS (2002) Conference summary: clinical issues in the prophylaxis, diagnosis, and treatment of anthrax. Emerg Infect Dis 8(2):222–225, http://www.cdc.gov/ncidod/EID/vol8no2/pdf/01-0521.pdf

    Article  Google Scholar 

  • Berge AC, Adaska JM, Sischo WM (2004) Use of antibiotic susceptibility patterns and pulsed-field gel electrophoresis to compare historic and contemporary isolates of multi-drug-resistant Salmonella enterica subsp. enterica serovar Newport. Appl Environ Microbiol 70(1): 318–323 Bosso JA, Mauldin PD (2006) Using interrupted time series analysis to assess associations of fluoroquinolone formulary changes with susceptibility of gram-negative pathogens and isolation rates of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 50(6):2106–2112

    Article  Google Scholar 

  • Casewell M, Friis C, Marco E, McMullin P, Phillips I (2003) The European ban on growth-­promoting antibiotics and emerging consequences for human and animal health. J Antimicrob Chemother 52(2):159–161

    Article  Google Scholar 

  • CDC (2006) Strategies for clinical management of MRSA in the community: summary of an experts meeting convened by the Centers for Disease Control and Prevention-March 2006. http://www.cdc.gov/ncidod/dhqp/pdf/ar/CAMRSA_ExpMtgStrategies.pdf

  • CDC (2008) Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food – 10 states, 2007. CDC MMWR Weekly 57(14):366–370, http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5714a2.htm

    Google Scholar 

  • Chan PA, Wakeman SE, Angelone A, Mermel LA (2008) Investigation of multi-drug resistant microbes in retail meats. Food Agr Environ 6(3–4):71–75, http://www.world-food.net/scientficjournal/2008/issue3/abstracts/abstract15.php

    Google Scholar 

  • Chander Y, Gupta S, Goyal S, Kumar K, Murray H (2006) Prevalence of antibiotic resistant bacteria on swine farms. In: Proceedings of ASA/ CSSA/ SSSA international annual meetings, Indianapolis, 12–16 Nov 2006, http://agronomy.cfans.umn.edu/People/FacultyDirectory/MurrayHelene/Publications/index.htm

  • Chee-Sanford JC, Aminov RI, Krapac IJ, Garrigues-Jeanjean N, Mackie RI (2001) Occurrence and diversity of tetracycline resistance genes in lagoons and groundwater underlying two swine production facilities. Appl Environ Biol 67(4):1494–1502, http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=92760

    Article  Google Scholar 

  • Christensen B, Sommer H, Rosenquist H, Nielsen N (2001) Risk assessment on Campylobacter jejuni in chicken products: First Edition. http://www.foedevaredirektoratet.dk/NR/rdonlyres/emmun3ukyfeweov2kt5f72bngkszsy3g4tfwzd2do4qlyn7my2bseotxcrdyknz7bndtoe2p6pkzmszbqabatvo4cje/rapport_jan2001.pdf

  • Cox LA Jr (2005) Some limitations of a proposed linear model for antimicrobial risk management. Risk Anal 25(6):1327–1332 Cox LA Jr (2007) Does concern-driven risk management provide a viable alternative to QRA? Risk Anal 27(1):27–43

    Article  Google Scholar 

  • Cox LA Jr (2008) What’s wrong with risk matrices? Risk Anal 28(2):497–512, http://www.ncbi.nlm.nih.gov/pubmed/18419665?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

    Article  Google Scholar 

  • Cox LA Jr, Babayev D, Huber W (2005) Some limitations of qualitative risk rating systems. Risk Anal 25(3):651–662 Cox LA Jr, Popken DA (2006) Quantifying potential human health impacts of animal antibiotic use: enrofloxacin and macrolides in chickens. Risk Anal 26(1):135–146

    Article  Google Scholar 

  • Cox LA Jr, Popken DA, Mathers J (2009) Human health risk assessment of penicillin/aminopenicillin resistance in enterococci due to penicillin use in food animals. Risk Anal 29(6):796–805

    Article  Google Scholar 

  • Cox LA, Popken DA (2004) Quantifying human health risks from virginiamycin used in chickens. Risk Anal 24(1):271–288

    Article  Google Scholar 

  • Cox LA, Popken DA (2002) A simulation model of human health risks from chicken-borne Campylobacter jejuni. Technology 9:55–84

    Google Scholar 

  • Cox LA Jr, Ricci PF (2008) Causal regulations vs. political will: why human zoonotic infections increase despite precautionary bans on animal antibiotics. Environ Int 34(4):459–475

    Article  Google Scholar 

  • Del Rosso JQ, Kim G (2009) Optimizing use of oral antibiotics in acne vulgaris. Dermatol Clin 27(1):33–42

    Article  Google Scholar 

  • Dunne EF, Fey PD, Kludt P et al (2000) Emergence of domestically acquired ceftriaxone-resistant Salmonella infections associated with AmpC beta-lactamase. JAMA 284(24):3151–3156, http://jama.ama-assn.org/cgi/content/full/284/24/3151

    Article  Google Scholar 

  • Eady AE, Cove JH, Layton AM (2003) Is antibiotic resistance in cutaneous Propionibacteria clinically relevant? Am J Clin Dermatol 4(12):813–831

    Article  Google Scholar 

  • Engemann CA, Keen PL, Knapp CW, Hall KJ, Graham DW (2008) Fate of tetracycline resistance genes in aquatic systems: migration from the water column to peripheral biofilms. Environ Sci Technol 42(14):5131–5136 Eypasch E, Lefering R, Kum CK, Troidl H (1995) Probability of adverse events that have not yet occurred: a statistical reminder. British Med J 311:619–620, http://www.bmj.com/cgi/content/full/311/7005/619

    Article  Google Scholar 

  • EPI-NEWS (2008) DANMAP 2007: antimicrobial consumption & resistance. EPI-NEWS – National surveillance of communicable diseases 47 [serial online]. http://www.ssi.dk/sw60246.asp

  • FAO/WHO/OIE (2008) Joint FAO/WHO/OIE expert meeting on critically important antimicrobials. Report of a meeting held in FAO, Rome, Italy, 26–30 Nov 2007. FAO, Rome, Italy, and WHO, Geneva, Switzerland. http://www.fao.org/ag/agn/agns/files/Prepub_Report_CIA.pdf

  • FDA-CVM (2001). Risk assessment on the human health impact of fl uoroquinolone resistant campylobacter associated with the consumption of chicken. Food and Drug Administration—Center for Veterinary Medicine—Available at http://www.fda.gov/AnimalVeterinary/SafetyHealth/RecallsWithdrawals/ucm042019.htm. Last accessed on 21 Dec 2009

  • FDA-CVM (US Food and Drug Administration – Center for Veterinary Medicine) (2003) Guidance for industry # 152: evaluating the safety of antimicrobial new animal drugs with regard to their microbiological effects on bacteria of human health concern. US Department of Health and Human Services, Food and Drug Administration, Center for Veterinary Medicine. http://www.fda.gov/cvm/Guidance/fguide152.pdf

  • FDA-CVM (US Food and Drug Administration, Center for Veterinary Medicine) (2004) Draft risk assessment of streptogramin resistance in Enterococcus faecium attributable to the use of streptogramins in animals, 23 Nov 2004. http://www.fda.gov/cvm/antimicrobial/SREF_RA_FinalDraft.pdf

  • Feller W (1968) An introduction to probability theory and its applications, volume I, 3rd edn. Wiley, New York

    Google Scholar 

  • Fritz JM, Woeltje KF (2007) Mycobacterium fortuitum. http://www.emedicine.com/med/topic1534.htm

  • Gardner D (2009) The science of fear: how the culture of fear manipulates your brain. Penguin Group, New York

    Google Scholar 

  • Gebreyes WA (2008) Salmonella in swine. FSRRN J IV(1). http://www.fsrrn.net/modules/content/index.php?id=157

  • Gebreyes WA, Thakur S, Morrow WE (2006) Comparison of prevalence, antimicrobial resistance, and occurrence of multidrug-resistant Salmonella in antimicrobial-free and conventional pig production. J Food Prot 69(4):743–748

    Google Scholar 

  • Gebreyes WA, Davies PR, Turkson P-K, Morrow WEM, Funk JA, Altier C, Thakur S (2004) Characterization of antimicrobial-resistant phenotypes and genotypes among Salmonella enteric recovered from pigs on farms, from transport trucks, and from pigs after slaughter. Int JFood Prot 67(4):698–705

    Google Scholar 

  • Goossens H, Ferech M, Coenen S, Stephens P, The European Surveillance of Antimicrobial Consumption Project Group (2007) Comparison of outpatient systemic antibacterial use in 2004 in the United States and 27 European countries. Clin Infect Dis 44:1091–1095, http://www.journals.uchicago.edu/doi/pdf/10.1086/512810

    Article  Google Scholar 

  • Gould IM (1999) A review of the role of antibiotic policies in the control of antibiotic resistance. J Antimicrob Chemother 43(4):459–465

    Article  Google Scholar 

  • Graham D (2005) Mechanisms of tetracycline resistance development in the environment as detected by real-time PCR. In: Presentation at the US EPA meeting on pharmaceuticals in the environment, Las Vegas, 23–25 Aug 2005. http://es.epa.gov/ncer/publications/workshop/8-23-2005/abstract/graham.html

  • Gray JT, Hungerford LL, Fedorka-Cray PJ, Headrick ML (2004) Extended-spectrum-cephalosporin resistance in Salmonella enteric isolates of animal origin. Antimicrob Agents Chemother 48(8):3179–3181, http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=478523

    Article  Google Scholar 

  • Greenstein G (2000) Nonsurgical periodontal therapy in 2000: a literature review. J Am Dent Assoc 131(11):1580–1592, http://jada.ada.org/cgi/content/full/131/11/1580

    Google Scholar 

  • Guay DR (2007) Topical clindamycin in the management of acne vulgaris. Expert Opin Pharmacother 8(15):2625–2664

    Article  Google Scholar 

  • Hayes Jr, Jensen H (2003) Lessons from the Danish ban on feed-grade antibiotics. Briefing paper O3-BP 41. Center for Agricultural and Rural Development, Iowa State University. http://www.card.iastate.edu/publications/DBS/PDFFiles/03bp41.pdf

  • Heike S, Stoob K, Hamscher G, Smit E, Seinen W (2006) Tetracyclines and tetracycline resistance in agricultural soils: microcosm and field studies. Microb Ecol 51(3):267–276

    Article  Google Scholar 

  • Helms RA, Herfindal ET, Quan DJ, Gourley DR (2006) Textbook of therapeutics: drug and disease management. Lippincott William & Wilkins, Philadelphia, PA

    Google Scholar 

  • Herron-Olson L, Fitzgerald JR, Musser JM, Kapur V (2007) Molecular correlates of host ­specialization in Staphylococcus aureus. PLoS ONE 2(10):e1120

    Article  Google Scholar 

  • Hughes P, Heritage J (2004) Antibiotic growth promoters in food animals. http://www.fao.org/docrep/007/y5159e/y5159e08.htm

  • Hurd HS, Brudvig J, Dickson J, Mirceta J, Polovinski M, Matthews N, Griffith R (2008) Swine health impact on carcass contamination and human foodborne risk. Public Health Rep 123(3):343–351

    Google Scholar 

  • Hurd HS, Malladi S (2008) A stochastic assessment of the public health risks of the use of macrolide antibiotics in food animals. Risk Anal 28(3):695–710

    Article  Google Scholar 

  • Inglis GD, McAllister TA, Busz HW, Yanke LJ, Morck DW, Olson ME, Read RR (2005) Effects of subtherapeutic administration of antimicrobial agents to beef cattle on the prevalence of antimicrobial resistance in Campylobacter jejuni and Campylobacter hyointestinalis. Appl Environ Microbiol 71(7):3872–3881

    Article  Google Scholar 

  • Kang M-S, Besser TE, Hancock DD, Porwollik S, McCelland M, Call DR (2006) Identification of specific gene sequences conserved in contemporary epidemic strains of Salmonella enteric. Appl Environ Microbiol 72:6938–6947, http://aem.asm.org/cgi/reprint/72/11/6938

    Article  Google Scholar 

  • Karatzas KGG, Randall LP, Webber M, Piddock LJV, Humphrey TJ, Woodward MJ, Coldham NG (2008) Phenotypic and proteomic characterization of multiply antibiotic-resistant variants of Salmonella enterica serovar Typhimurium selected following exposure to disinfectants. Appl Environ Microbiol 74(5):1508–1516

    Article  Google Scholar 

  • KAW (Keep Antibiotics Working) web site (2009) http://www.keepantibioticsworking.org/new/top_act.cfm (This is KAW’s web site, and summarizes the top actions that they advocate. See also http://www.keepantibioticsworking.com/new/resources_library.cfm?refID=36396). Retrieved 20 Nov 2009

  • KAW (Keep Antibiotics Working) (2008) MRSA and animal agriculture: a need to understand the public health impact. http://www.keepantibioticsworking.com/new/indepth_mrsa.cfm

  • Kertzman MGM, Smeets JGE, Boukes FS, Goudswaard AN (2008) Summary of the practice guideline ‘Acne’ (second revision) from the Dutch College of General Practitioners. Ned Tijdschr Geneeskd 152(22):1271–1275, http://lib.bioinfo.pl/meid:57443

    Google Scholar 

  • Klevens RM et al (2007) Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 298(15):1763–1771, http://www.cdc.gov/ncidod/dhqp/pdf/ar/InvasiveMRSA_JAMA2007.pdf

    Article  Google Scholar 

  • Klein NC, Cunha BA (1995) Tetracyclines. Med Clin North Am 79(4):789–801

    Google Scholar 

  • Kleinfelder JW, Muller RF, Lange DE (1999) Antibiotic susceptibility of putative periodontal pathogens in advanced periodontitis patients. J Clin Periodontol 26(6):347–351

    Article  Google Scholar 

  • Lorian V (2005) Antibiotics in laboratory medicine. Lippincott Williams & Wilkins, Philadelphia, PA

    Google Scholar 

  • Langner A, Chu A, Goulden V, Ambroziak M (2008) A randomized, single-blind comparison of topical clindamycin + benzoyl peroxide and adapalene in the treatment of mild to moderate facial acne vulgaris. Br J Dermatol 158(1):122–129

    Article  Google Scholar 

  • Lawley R (2007) Campylobacter takes over as number one. Food safety watch 2007. http://www.foodsafetywatch.com/public/471.cfm?sd=2

  • Lewis HC, Molbak K, Reese C, Aarestrup FM, Selchau M, Sorum M, Skov R (2008) Pigs as a source of methicillin-resistant Staphylococcus aureus infections in humans, Denmark. Emerg Infect Dis 14(9):1383–1389, http://www.cdc.gov/eid/content/14/9/pdfs/1383.pdf

    Article  Google Scholar 

  • Lundergan WP (2003) Periodontal antibiotic/antimicrobial therapy. In: Hall WB (ed) Critical decisions in periodontology. BC Decker, London, http://dentistry.tums.ac.ir/Files/lib/My%20Web%20Sites/CD_PER%20(E)/docs/ch051.pdf

    Google Scholar 

  • Luangtongkum T, Morishita TY, Ison AJ, Huang S, McDermott PF, Zhang Q (2006) Effect of conventional and organic production practices on the prevalence and antimicrobial resistance of Campylobacter spp. in poultry. Appl Environ Microbiol 72(5):3600–3607

    Article  Google Scholar 

  • MacDonald JM, McBride WD (2009) The transformation of U.S. livestock agriculture: scale, efficiency, and risks. Economic Research Service/USDA Economic Information Bulletin No. (EIB-43), Jan 2009. http://www.ers.usda.gov/Publications/EIB43

  • MacKenzie FM, Lopez-Lozano JM, Monnet DL, Stuart D, Beyaert A, Wilson R, Gould IM (2007) Temporal relationship between prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in one hospital and prevalence of MRSA in the surrounding community: a time-series analysis. J Hosp Infect 67(3):225–231

    Article  Google Scholar 

  • McKeage K, Keating GM (2008) Clindamycin/benzoyl peroxide gel (BenzaClin): a review of its use in the management of acne. Am J Clin Dermatol 9(3):193–204

    Article  Google Scholar 

  • Merck (2008) Acne Vulgaris. The Merck manuals online medical library. http://www.merck.com/mmpe/sec10/ch111/ch111b.html#sec10-ch111-ch111b-182

  • Mirbagheri SA, Hasibi M, Abousari M, Rashidi A (2006) Triple, standard quadruple and ampicillin-sulbactam-based quadruple therapies for H pylori eradication: a comparative three-armed randomized clinical trial. World J Gastroenterol 12(30):4888–4891, http://www.wjgnet.com/1007-9327/12/4888.asp

    Google Scholar 

  • Mølbak K (2004) Spread of resistant bacteria and resistance genes from animals to humans–the public health consequences. J Vet Med B Infect Dis Vet Public Health 51(8–9):364–369

    Article  Google Scholar 

  • Monnet DL, MacKenzie FM, López-Lozano JM, Beyaert A, Camacho M, Wilson R, Stuart D, Gould IM (2004) Antimicrobial drug use and methicillin-resistant Staphylococcus aureus, Aberdeen, 1996–2000. Emerg Infect Dis 10(8):1432–1441

    Article  Google Scholar 

  • Monnet DL, Frimodt-Moller N (2001) Antimicrobial-drug use and methicillin-resistant Staphylococcus aureus. Lett Emerg Infect Dis 7(1):161–163, http://www.cdc.gov/ncidod/eid/vol7no1/monnet_letter.htm

    Article  Google Scholar 

  • Morgan M (2008) Methicillin-resistant Staphylococcus aureus and animals: zoonosis or humanosis? J Antimicrob Chemother 62(6):1181–1187

    Article  Google Scholar 

  • NARMS (National Antimicrobial Resistance Monitoring System) (2009) NARMS veterinary Isolates. http://www.ars.usda.gov/Main/docs.htm?docid=6750&page=4#Tables

  • NIH (2008) E. coli enteritis. US National Library of Medicine (MedlinePlus), National Institute of Health. http://www.nlm.nih.gov/medlineplus/ency/article/000296.htm#Treatment

  • Olsvik B, Tenover FC (1993) Tetracycline resistance in periodontal pathogens. Clin Infect Dis 16(Sup 4):S310–S313

    Article  Google Scholar 

  • Ozolins M, Eady EA, Avery A, Cunliffe WJ, O’Neill C, Simpson NB, Williams HC (2005) Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne. Health Technol Assess 9(1):iii-212

    Google Scholar 

  • Patchanee P, Zewde BM, Tadesse DA, Hoet A, Gebreyes WA (2008) Characterization of multidrug-resistant Salmonella enterica serovar Heidelberg isolated from humans and animals. Foodborne Pathog Dis 5(6):839–851

    Article  Google Scholar 

  • Peak N, Knapp CW, Yang RK, Smith MM, Marilyn S, Aga DS, Graham DW (2007) Abundance of six tetracycline resistance genes in wastewater lagoons at cattle feedlots with different antibiotic use strategies. Environ Microbiol 9(1):143–151, http://www.ingentaconnect.com/content/bsc/emi/2007/00000009/00000001/art00022;jsessionid=2f0n

    Article  Google Scholar 

  • Pew (2009) Pew applauds introduction of preservation of antibiotics for medical treatment act. http://www.saveantibiotics.org/newsroom/pr_17march2009.html. Retrieved 20 Nov 2009

  • Phillips I (2007) Withdrawal of growth-promoting antibiotics in Europe and its effects in relation to human health. Int J Antimicrob Agents 30(2):101–107

    Article  Google Scholar 

  • Pu S, Han F, Ge B (2009) Isolation and characterization of methicillin-resistant Staphylococcus aureus from Louisiana retail meats. Appl Environ Microbiol 75(1):265–267, http://www.ncbi.nlm.nih.gov/pubmed/18978079

    Article  Google Scholar 

  • Pugh DM (2002) The EU precautionary bans of animal feed additive antibiotics. Toxicol Lett 128(1–3):35–44 Ricci V, Piddock LJV (2009) Ciprofloxacin selects for multidrug resistance in Salmonella enteric serovar Typhimurium mediated by at least two different pathways. J Antimicrob Chemother 63(5):909–916, http://jac.oxfordjournals.org/cgi/content/abstract/63/5/909

    Article  Google Scholar 

  • Rodrigues RM, Goncalves C, Souto R, Feres-Filho EJ, Uzeda M, Colombo AP (2004) Antibiotic resistance profile of the subgingival microbiota following systemic or local tetracycline therapy. J Clin Periodontol 31(6):420–427

    Article  Google Scholar 

  • Romanowicz M, Stephenson JJ, Del Rosso JQ, Lenhart G (2008) Healthcare utilization and costs of patients with rosacea in an insured population. J Drugs Dermatol 7(1):41–49, http://findarticles.com/p/articles/mi_m0PDG/is_/ai_n24258971

    Google Scholar 

  • Ross JI, Snelling A M, Carnegie E, Coates P, Cunliffe WJ, Bettoli V, Tosti G, Katsambas A, Galvan Peréz Del Pulgar JI, Rollman O, Török L, Eady EA, Cove JH (2003) Antibiotic-resistant acne: lessons from Europe. Br J Dermatol 148(3): 467–478 Ross JI, Snelling AM, Carnegie E, Coates P, Cunliffe WJ, Bettoli V, Tosti G, Katsambas A, Galvan Peréz Del Pulgar JI, Rollman O, Török L, Eady EA, Cove JH (2004) Antibiotic-resistant acne: lessons from Europe. Br J Dermatol 150(2):369–370, http://www3.interscience.wiley.com/journal/118864658/abstract

    Article  Google Scholar 

  • Russell SSF (2008) General researchers follow strain of drug-resistant bacteria. San Francisco Chronicle, 15 Jan 2008. http://www.sfgate.com/cgi-bin/article.cgi?f=/c/a/2008/01/15/MNUKUDB6D.DTL&feed=rss.news

  • Sack DA, Kaminsky DC, Sack RB, Itotia JN, Arthur RR, Kapikian AZ, Orskov F, Orskov I (1978) Prophylactic doxycycline for travelers’ diarrhea. Results of a prospective double-blind study of Peace Corps volunteers in Kenya. N Engl J Med 298(14):758–763 Schneider A (2008) Potentially fatal bacteria found in pigs, farmworkers. Seattle pi.com 8 June 2008. http://seattlepi.nwsource.com/local/366301_pigmrsa09.html

  • Simmons S (2007) In The News 2006–2007: bipartisan bill curtails routine use of antibiotics in animal feed. Vermont Journal of Environmental Law. http://www.vjel.org/news/NEWS100074.html. Retrieved 20 Nov 2009

  • Simonart T, Dramaix M, De Maertelaer V (2008) Efficacy of tetracyclines in the treatment of acne vulgaris: a review. Br J Dermatol 158(2):208–216 Singer RS, Cox LA Jr, Dickson JS, Hurd HS, Phillips I, Miller GY (2007). Modeling the relationship between food animal health and human foodborne illness. Prev Vet Med 79(2–4): 186–203

    Google Scholar 

  • Slaughter LM (2008) Chairwoman Slaughters statement on agricultural subcommittee hearing on animal health, antibiotics. 25th Sep 2008. http://www.ncrlc.com/antibiotics-agri_page2.html

  • Smith TC, Male MJ, Harper AL, Kroeger JS, Tinkler GP, Moritz ED, Capuano AW, Herwaldt LA, Diekema DJ (2009) Methicillin-resistant Staphylococcus aureus (MRSA) strain ST398 is present in midwestern U.S. swine and swine workers. PLoS ONE 4(1):e4258

    Article  Google Scholar 

  • Smith TC, Male MF, Harper AL, Moritx-Kolev E, Kroeger JS, Dickema DJ, Herwaldt LA (2008a) Isolation of methicillin-resistant Staphylococcus aureus (MRSA) from swine in the midwestern United States. In: Presentation at the international conference on emerging infectious disease (ICEID), Atlanta, 16–19 Mar 2008. http://www.public-health.uiowa.edu/CEID/Posters/Smith%20ICEID%20presentation%203-18-08.pdf

  • Smith TC (2008b) Dr. Tara Smith explores zoonotic MRSA. Center for Emerging Infectious Diseases Newsletter, vol 9, Summer 2008. http://www.public-health.uiowa.edu/CEID/Center_news/CEID_news_Sept_18_2008.pdf

  • Smith JL, Drum DJV, Daj Y, Kim JM, Sanchez S, Maurer JJ, Hofacre CL, Lee MD (2007) Impact of antimicrobial usage on antimicrobial resistance in commensal Escherichia coli strains colonizing broiler chickens. Appl Environ Microbiol 73:1404–1414

    Article  Google Scholar 

  • Stern NJ, Robach MC (2003) Enumeration of Campylobacter spp. in broiler feces and in corresponding processed carcasses. J Food Prot 66(9):1557–1563

    Google Scholar 

  • Stern RS (2000) Medication and medical service utilization for acne 1995–1998. J Am Acad Dermatol 43(6):1042–1048

    Article  Google Scholar 

  • Swenson JM, Wallace RJ, Silcox VA, Thornsberry C (1985) Antimicrobial susceptibility of five subgroups of Mycobacterium fortuitum and Mycobacterium chelonae. Antimicrob Agents Chemother 28(6):807–811, http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=180333

    Article  Google Scholar 

  • Swanson JK (2003) Antibiotic resistance of Propionibacterium acnes in acne vulgaris. Dermatol Nurs 15(40):359–362, http://findarticles.com/p/articles/mi_hb6366/is_4_15/ai_n29025578/print?tag=artBody;col1

    Google Scholar 

  • Roberts M (2003) Tetracycline therapy: update. Clin Inf Dis 36:462–467, http://www.journals.uchicago.edu/doi/pdf/10.1086/367622

    Article  Google Scholar 

  • Tacconelli E, De Angelis G, Cataldo MA, Pozzi E, Cauda R (2008) Does antibiotic exposure increase the risk of methicillin-resistant Staphylococcus aureus (MRSA) isolation? A systematic review and meta-analysis. J Antimicrob Chemother 61(1):26–38

    Article  Google Scholar 

  • Tan AW, Tan HH (2005) Acne vulgaris: a review of antibiotic therapy. Expert Opin Pharmacother 6(3):409–418

    Article  Google Scholar 

  • Thakur S, Tadesse DA, Morrow M, Gebreyes WA (2007) Occurrence of multidrug resistant Salmonella in antimicrobial-free (ABF) swine production systems. Vet Microbiol 125(3–4):362–367

    Article  Google Scholar 

  • Thevarajah S, Balkrishnan R, Camacho FT, Feldman SR, Fleischer AB Jr (2005) Trends in prescription of acne medication in the US: shift from antibiotic to non-antibiotic treatment. J Dermatolog Treat 16(4):224–228

    Article  Google Scholar 

  • UCS (Union of Concerned Scientists) (2009) Tell congress: keep antibiotics working. https://secure3.convio.net/ucs/site/Advocacy?cmd=display&page=UserAction&id=1924 (Union of Concerned Scientists call for letters to members of Congress). Retrieved 20 Nov 2009

  • Valtonen MV, Valtonen VV, Salo OP, Makela PH (1976) The effect of tetracycline treatment for acne vulgaris on the occurrence of R factors in the intestinal flora of man. Br J Dermatol 4:71–74, published online 2006

    Google Scholar 

  • Van Immerseel F, Rood JI, Moore RJ, Titball RW (2009) Rethinking our understanding of the pathogenesis of necrotic enteritis in chickens. Trends Microbiol 17(1):32–36

    Article  Google Scholar 

  • Van Loo IHM, Diederen BMW, Savelkout PHM, Woudenberg JHC, Roosendaal R, van Belkum A, Lemmens-den Toom N, Verhulst C, van Keulen HJ, Kluytmans JAJW (2007) Methicillin-resistant Staphylococcus aureus in meat products, the Netherlands. Emerg Infect Dis 13(11):1753–1755, http://www.cdc.gov/EID/content/13/11/1753.htm

    Article  Google Scholar 

  • Varma JK, Marcus R, Stenzel SA, Hanna SS, Gettner S, Anderson BJ, Hayes T, Shiferaw B, Crume TL, Joyce K, Fullerton KE, Voetsch AC, Angulo FJ (2006) Highly resistant Salmonella Newport-MDRAmpC transmitted through the domestic US food supply: a FoodNet case–­control study of sporadic Salmonella Newport infections, 2002–2003. J Infect Dis 194(2):222–230 Vedder T (2008) MRSA found in store-bought pork. Available at http://www.klewtv.com/news/local/33624114.html

    Article  Google Scholar 

  • Vierikko A, Hänninen M-J, Siitonen A, Ruutu P, Rautelin H (2004) Domestically acquired Campylobacter infections in Finland. Emerg Infect Dis 10(1):127–130, http://www.cdc.gov/ncidod/EID/vol10no1/03-0636.htm

    Article  Google Scholar 

  • Villedieu A, Diaz-Torres ML, Hunt N, McNab R, Spratt DA, Wilson M, Mullany P (2003) Prevalence of tetracycline resistance genes in oral bacteria. Antimicrob Agents Chemother 47(3):878–882, http://aac.asm.org/cgi/content/full/47/3/878

    Article  Google Scholar 

  • Weber SG, Gold HS, Hooper DC, Karchmer AW, Carmeli Y (2003) Fluoroquinolones and the risk for methicillin-resistant Staphylococcus aureus in hospitalized patients. Emerg Infect Dis 9(11):1415–1422

    Article  Google Scholar 

  • Weigel RM, Isaacson RE (2004) Patterns of transmission of antibiotic resistant Salmonella to swine. Research Report 99–046, National Pork Producers Council. http://www.pork.org/PorkScience/Documents/REPORT%2004-99-046-Weigel-U%20of%20IL.pdf

  • World Health Organization (2005) Drug-resistant Salmonella. Fact Sheet # 139, revised Apr 2005. http://www.who.int/mediacentre/factsheets/fs139/en/

  • Wulf MW, Sørum M, van Nes A, Skov R, Melchers WJ, Klaassen CH, Voss A (2008) Prevalence of methicillin-resistant Staphylococcus aureus among veterinarians: an international study. Clin Microbiol Infect 14(1):29–34 Zaidi MB, Leon V, Canche C, Perez C, Zhao S, Hubert SK, Abbott J, Blickenstaff K, McDermott PF (2007) Rapid and widespread dissemination of multidrug-resistant blaCMY-2 Salmonella Typhimurium in Mexico. J Antimicrob Chemother 60(2):398–401

    Article  Google Scholar 

  • Zeichner SL (1998) Tetracycline update. Pediatr Rev 19:32

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Louis Anthony Cox, Jr

About this chapter

Cite this chapter

Cox, L.A. (2012). Managing Real and Perceived Risks: Animal Antibiotics and Drug-Resistant Infections. In: Improving Risk Analysis. International Series in Operations Research & Management Science, vol 185. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6058-9_6

Download citation

Publish with us

Policies and ethics