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Molecular Mechanisms of Tumor Metastasis

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Molecular Pathology of Neoplastic Gastrointestinal Diseases

Part of the book series: Molecular Pathology Library ((MPLB,volume 7))

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Abstract

Metastatic disease is the major cause of cancer-related death. Treatment of advanced metastatic disease is nonexistent in the vast majority of tumor cases. Even as the study of metastasis has exploded over the past few years, many questions still remain. In this chapter, we will provide the groundwork for a general understanding of the biology of metastasis with special emphasis on tumor microenvironment and cell heterogeneity; genetic changes in tumor cells associated with metastasis; importance of epithelial to mesenchymal transition in metastasis; senescence and cancer stem cell theory; circulating tumor cells and timing of dissemination and metastasis. We also discuss colorectal and pancreatic carcinomas, two specific cancers of the digestive organs, regarding mechanisms, detection, models, and therapeutic targeting of invasion and metastasis.

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Authors and Affiliations

  1. Department of Medicine, Gastroenterology Division, University of Pennsylvania School of Medicine, 421 Curie Blvd., Philadelphia, PA, 19104, USA

    Andrew D. Rhim M.D. & Hiroshi Nakagawa M.D., Ph.D.

  2. Solid Tumor Oncology, Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Avenue, R35, Cleveland, OH, 44195, USA

    Davendra Sohal M.D., M.P.H.

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    Antonia R. Sepulveda

  2. Division of Gastroenterology, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA

    John P. Lynch

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Rhim, A.D., Sohal, D., Nakagawa, H. (2013). Molecular Mechanisms of Tumor Metastasis. In: Sepulveda, A., Lynch, J. (eds) Molecular Pathology of Neoplastic Gastrointestinal Diseases. Molecular Pathology Library, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-6015-2_13

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