Molecular Pathology of Inflammatory Bowel Disease-Associated Neoplasia

Chapter
Part of the Molecular Pathology Library book series (MPLB, volume 7)

Abstract

Patients with inflammatory bowel diseases (ulcerative colitis and Crohn’s disease) have a greater risk of developing colorectal cancer (CRC) as compared to patients without colitis, requiring increased surveillance colonoscopy. Chronic colitis may progress to dysplasia and in turn dysplastic lesions carry a high risk of progression to adenocarcinoma.

Although many molecular players are common with sporadic colorectal carcinogenesis, since IBD-associated dysplasia and cancers are initiated in a specific inflammatory milieu, these lesions are significantly different at the molecular level. This chapter will review the most recent advances in molecular alterations observed in IBD-associated neoplastic lesions. Importantly, in view of these differences, approaches used for early detection and specific targeted therapies may differ between IBD-associated and sporadic forms of CRC and pre-cancer lesions.

Keywords

Estrogen Adenocarcinoma Adenoma Prostaglandin Gastritis 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Takeshi Uehara
    • 1
  • Deqin Ma
    • 2
  • Antonia R. Sepulveda
    • 3
  1. 1.Department of Laboratory MedicineShinshu University School of MedicineMatsumotoJapan
  2. 2.Department of PathologyUniversity of Iowa Hospitals and ClinicsIowa CityUSA
  3. 3.Department of Pathology & Cell BiologyColumbia UniversityNew YorkUSA

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