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Overview of Colorectal Cancer

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Colorectal Cancer Screening and Computerized Tomographic Colonography

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Abstract

Colorectal cancer (CRC) (adenocarcinoma of the large bowel) arises from a neoplastic process involving the epithelial layer of the intestine. In most CRC, the process begins as a benign polyp or adenoma. The adenoma undergoes a transformation to cancer through a series of molecular changes. Early in the process, the cancer can be treated easily with removal of the adenoma or early stage cancer. Thus, as expected from the nature of this disease, prevention and screening have likely reduced the incidence and mortality rates of this disease. The goal of this chapter is to provide an overview of CRC as well as an understanding of the rational for screening for this cancer.

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  1. Department of Gastroenterology, White River Junction VA Medical Center, White River Junction, VT, USA

    Joseph C. Anderson M.D. & Douglas J. Robertson M.D., M.P.H.

  2. Geisel School of Medicine at Dartmouth, Hanover, NH, USA

    Douglas J. Robertson M.D., M.P.H.

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  1. Medical Center, Department of Gastroenterology, Walter Reed National Military, 8901 Wisconsin Ave., Bethesda, 20889, Maryland, USA

    Brooks D. Cash

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Anderson, J.C., Robertson, D.J. (2013). Overview of Colorectal Cancer. In: Cash, B. (eds) Colorectal Cancer Screening and Computerized Tomographic Colonography. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5943-9_1

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