Acceleration of Puberty Onset in Female Mice by Male Urinary Odours: Chemosensory, Physiological and Neuroendocrine Mechanisms



Among many environmental factors, social factors, especially olfactory cues, can profoundly influence the timing of puberty onset. This is particularly well established in the house mouse (Mus musculus) where male urinary odours have been shown to accelerate puberty onset in prepubertal females. The urinary chemosignal(s) accelerate vaginal opening, the first oestrus and uterine growth, three parameters indicative of puberty onset. Several puberty-accelerating chemosignals, the majority of which are small volatile ligands bound to the major urinary proteins (MUPs), have been isolated from male urine; however when they are efficient, it is usually to a lower extent than male urine. These puberty-accelerating chemosignals are detected by the accessory olfactory system and the olfactory information is then transmitted to the hypothalamus. Among various potential neurological targets of the olfactory information, we focus on the hypothalamic neurons expressing neuropeptide kisspeptin, identified as a major regulator of the hypothalamic–pituitary–gonadal axis governing puberty onset. Preliminary results indicate that male odours seems to accelerate the structural changes usually observed in this neuronal population at puberty onset, thus suggesting that it could be a central hypothalamic relay of pheromonal information.


Luteinizing Hormone GnRH Neuron Uterine Weight Main Olfactory Bulb Vaginal Opening 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The experiments reported in this chapter were performed with the support of the French National Research Agency (ANR) grants: ANR-PHEROSEX, -MALE-EFFECT, -BIMUCE; Mélanie Jouhanneau is a PhD student supported by INRA PHASE Department and Région Centre. Matthieu Keller is a CNRS permanent research fellow.


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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.UMR Physiologie de la Reproduction et des ComportementsUMR 0085 INRA—UMR 7247 CNRS—Université de ToursNouzillyFrance

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