Hypoxia-Directed Drug Strategies to Target the Tumor Microenvironment

Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 772)

Abstract

Hypoxia is an important component of the tumor microenvironment and has been the target of drug discovery efforts for almost half a century. These efforts have evolved from offsetting the impact of hypoxia on radiotherapy with oxygen-mimetic radiosensitizers to using hypoxia as a means to selectively target tumors. The more recent description of hypoxia-inducible factors and their role in the hypoxia response network has revealed a host of new drug targets to selectively target tumors. We are developing hypoxia-directed drugs in each of the following areas: novel radiosensitizers for hypofractionated radiotherapy, a second-generation benzotriazine di-N-oxide hypoxia-activated prodrug, and a hypoxia-inducible factor-1–dependent cytotoxin that targets glucose transport. These projects are discussed in the context of hypoxia-directed drug discovery.

Keywords

Hypoxia Drug discovery Nitroimidazole Radiosensitizer Hypoxia-activated prodrug Biomarker Tirapazamine SN30000 HIF-1α Glucose transport 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Auckland Cancer Society Research CentreThe University of AucklandAucklandNew Zealand

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