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Tumor Microenvironment and Cellular Stress pp 205–227Cite as

miR-210: Fine-Tuning the Hypoxic Response

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 772)

Abstract

Hypoxia is a central component of the tumor microenvironment and represents a major source of therapeutic failure in cancer therapy. Recent work has provided a wealth of evidence that noncoding RNAs and, in particular, microRNAs, are significant members of the adaptive response to low oxygen in tumors. All published studies agree that miR-210 specifically is a robust target of hypoxia-inducible factors, and the induction of miR-210 is a consistent characteristic of the hypoxic response in normal and transformed cells. Overexpression of miR-210 is detected in most solid tumors and has been linked to adverse prognosis in patients with soft-tissue sarcoma, breast, head and neck, and pancreatic cancer. A wide variety of miR-210 targets have been identified, pointing to roles in the cell cycle, mitochondrial oxidative metabolism, angiogenesis, DNA damage response, and cell survival. Additional microRNAs seem to be modulated by low oxygen in a more tissue-specific fashion, adding another layer of complexity to the vast array of protein-coding genes regulated by hypoxia.

Keywords

  • Hypoxia
  • microRNA
  • Cancer
  • Biomarker
  • miR-210
  • Mitochondria
  • Apoptosis
  • Metabolism

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Acknowledgments

This work is supported in part by funding from the National Institutes of Health (NIH 1R01 CA155332-01 to M.I.) and the American Cancer Society (M.I., X.H.). X.H. is a Liz Tilberis Scholar of the Ovarian Cancer Research Fund.

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Authors and Affiliations

  1. Department of Medicine, Indiana University, 980 W. Walnut Street Walther Hall, Room C225, Indianapolis, IN, 46202, USA

    Mircea Ivan M.D., Ph.D.

  2. Department of Microbiology and Immunology, Indiana University, 980 W. Walnut Street Walther Hall, Room C225, Indianapolis, IN, 46202, USA

    Mircea Ivan M.D., Ph.D.

  3. Magee-Womens Research Institute, Department of Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh School of Medicine, B407, 204 Craft Ave, Pittsburgh, PA, 15213, USA

    Xin Huang Ph.D.

  4. Women’s Cancer Research Center, University of Pittsburgh Cancer Institute, B407, 204 Craft Ave, Pittsburgh, PA, 15213, USA

    Xin Huang Ph.D.

Authors
  1. Mircea Ivan M.D., Ph.D.
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  2. Xin Huang Ph.D.
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Correspondence to Mircea Ivan M.D., Ph.D. or Xin Huang Ph.D. .

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Editors and Affiliations

  1. Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

    Constantinos Koumenis

  2. Cancer Research, Gray Institute for Radiation Oncology, Oxford, United Kingdom

    Ester Hammond

  3. Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA

    Amato Giaccia

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Ivan, M., Huang, X. (2014). miR-210: Fine-Tuning the Hypoxic Response. In: Koumenis, C., Hammond, E., Giaccia, A. (eds) Tumor Microenvironment and Cellular Stress. Advances in Experimental Medicine and Biology, vol 772. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5915-6_10

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