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Prominin-1 (CD133) and the Cell Biology of Neural Progenitors and Their Progeny

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Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 777))

Abstract

Our group discovered prominin-1 in search for markers to study the cell polarity of neural stem and progenitor cells in the developing brain. Over the past 15 years, prominin-1, also called CD133, has not only become a frequently used marker of neural stem cells and neural cancer stem cells, as is in fact the case of somatic (cancer) stem cells in general, but has also been used to understand the symmetric versus asymmetric division of the neural stem cells in the context of their apical-basal polarity. Moreover, studying prominin-1 on neural stem cells has revealed a novel fate of the midbody, that is, midbody release, and key differences in this release between normal stem cells and cancer-derived cells. Other subcellular aspects of neural stem cells, the understanding of which has been promoted by studying prominin-1, pertain to the organization of plasma membrane protrusions and the membrane microdomains they contain. Of particular relevance in this context is the primary cilium of neuroepithelial cells and its transformation into the outer segment of retinal photoreceptor cells, a process in which prominin-1 exerts a vital role.

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Acknowledgements

W.B.H. was supported by grants from the Deutsche Forschungsgemeinschaft (SFB 655, A2; TRR 83, Tp6) and the European Research Council (250197), by the Deutsche Forschungsgemeinschaft-funded Center for Regenerative Therapies Dresden and by the Fonds der Chemischen Industrie.

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Authors and Affiliations

  1. Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307, Dresden, Germany

    Alex M. Sykes & Wieland B. Huttner M.D.

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  1. Alex M. Sykes
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  2. Wieland B. Huttner M.D.
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Correspondence to Wieland B. Huttner M.D. .

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  1. , Biotechnological Centre (BIOTEC), Dresden University of Technology, Fetscherstr. 74, Dresden, 01307, Sachsen, Germany

    Denis Corbeil

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Sykes, A.M., Huttner, W.B. (2013). Prominin-1 (CD133) and the Cell Biology of Neural Progenitors and Their Progeny. In: Corbeil, D. (eds) Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology. Advances in Experimental Medicine and Biology, vol 777. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5894-4_6

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