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MSC Niche for Hematopoiesis

  • Daniel Lucas
  • Sandra Pinho
  • Paul S. Frenette
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

Blood cell production is maintained throughout life by hematopoietic stem cells (HSC), which reside in specific areas of the bone marrow (BM) referred to as niches. These niches regulate the self-renewal, proliferation, and migration of HSC and also integrate signals from the periphery to respond to the hematopoietic demand. In the last decade, several putative cellular components of the HSC niche have been identified. Here, we briefly review current knowledge on different putative niche cells and their regulation.

Keywords

Hematopoietic Stem Cell Bone Marrow Macrophage Bone Marrow Niche Hematopoietic Microenvironment Hematopoietic Stem Cell Niche 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Medicine, Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine ResearchAlbert Einstein College of MedicineBronxUSA
  2. 2.Department of Cell Biology, Ruth L. and David S. Gottesman Institute for Stem Cell and regenerative Medicine ResearchAlbert Einstein College of MedicineBronxUSA
  3. 3.Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine ResearchAlbert Einstein College of MedicineBronxUSA

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