MSCs as Therapeutics

  • Arnold I. Caplan
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)


Marrow has long been recognized as a source of osteoprogenitor cells. Such cells are a member of a heterogeneous group of cells that I have termed mesenchymal stem cells (MSCs) because they can be induced to form a number of differentiated mesenchymal cell types. With the realization that many of these MSCs are perivascular cells, pericytes, also comes the realization that they secrete a large array of bioactive molecules that are immunomodulator and trophic. In this context, the differentiation capabilities are less important than their medicinal capacity and their regenerative potential in a number of diseases and medical conditions. Thus, we propose the suggestion that they could be called medicinal signaling cells (MSCs).


Amyotrophic Lateral Sclerosis Mesenchymal Stem Cell Demineralized Bone Matrix Fracture Repair Osteoprogenitor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Biology, Skeletal Research CenterCase Western Reserve UniversityClevelandUSA

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