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MSCs for Diabetes

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Mesenchymal Stromal Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Mesenchymal stromal cells (also often referred to as mesenchymal stem cells, MSCs) hold promise as a powerful tool in the treatment of human diseases. Because of their potent immunomodulatory properties, they are likely to impact in a positive fashion diseases in which inflammation and/or autoimmunity play a key role. Furthermore, they have been shown to possess plasticity as precursors of cells of various types. Their differentiation potential could span cell differentiation products that do not normally derive from the mesoderm, including cells of endodermal origin. These two remarkable features make them potentially ideal candidates for regenerative approaches. This chapter will briefly discuss the current state of the art in the emerging field of their use for autoimmune type 1 diabetes.

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Authors and Affiliations

  1. Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, 33136, USA

    Luca Inverardi, Giacomo Lanzoni, Juan Dominguez-Bendala & Camillo Ricordi

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  1. Luca Inverardi
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  2. Giacomo Lanzoni
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  3. Juan Dominguez-Bendala
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  4. Camillo Ricordi
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Correspondence to Camillo Ricordi .

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  1. Madison School of Medicine and Public He, Department of Medicine, Hematology/Oncol, University of Wisconsin, 1111 Highland Avenue MC2275, Madison, 53705, USA

    Peiman Hematti

  2. Princess Margaret Hospital, Cell Therapy Program, University of Toronto, University Avenue 610, Toronto, M5G 2M9, Ontario, Canada

    Armand Keating

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Inverardi, L., Lanzoni, G., Dominguez-Bendala, J., Ricordi, C. (2013). MSCs for Diabetes. In: Hematti, P., Keating, A. (eds) Mesenchymal Stromal Cells. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-5711-4_33

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