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MSCs for Autoimmune Diseases

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Mesenchymal Stromal Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Mesenchymal stromal/stem cells (MSC), more correctly called multipotent mesenchymal stromal cells, are being examined for the treatment of autoimmune disease (AD) based on their in vitro antiproliferative properties, efficacy in animal models, apparent low acute toxicity and the early positive anecdotal outcomes in human acute graft versus host disease and AD. Small phase I/II clinical trials in Crohn’s disease, multiple sclerosis and systemic lupus erythematosus have been published suggesting acceptable feasibility and safety, and some positive clinical responses. An unpublished large randomised clinical trial in Crohn’s disease has failed to confirm a clear clinical advantage over placebo, although trial design may have confounded outcomes. Multidisciplinary groups are collaborating to ensure maximal use of available resources to establish the place, if any, of MSCs in the treatment of AD.

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  1. Department of Rheumatology, University of Basel, Felix Platter Spital, Basel, Switzerland

    Alan Tyndall & Chiara Bocelli

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Correspondence to Alan Tyndall .

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  1. Madison School of Medicine and Public He, Department of Medicine, Hematology/Oncol, University of Wisconsin, 1111 Highland Avenue MC2275, Madison, 53705, USA

    Peiman Hematti

  2. Princess Margaret Hospital, Cell Therapy Program, University of Toronto, University Avenue 610, Toronto, M5G 2M9, Ontario, Canada

    Armand Keating

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Tyndall, A., Bocelli, C. (2013). MSCs for Autoimmune Diseases. In: Hematti, P., Keating, A. (eds) Mesenchymal Stromal Cells. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-5711-4_28

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