Abstract
Stem cell history started almost a century ago with administration of bone marrow by mouth to the patients with anemia and leukemia [1]. At that time, in the early 1900s, European scientists realized that all blood cells originate from one particular “stem cell” located within the bone marrow, tissue where the entire hematopoiesis take place. Early studies with animals quickly revealed that the bone marrow was the organ most sensitive to the damaging effects of radiation. Very soon, it became clear that reinfusion of marrow cells could rescue lethally irradiated animals. Mice with defective bone marrow could be restored to health with infusions into the blood stream of marrow taken from other mice [2].
The beginning is the most important part of the work.
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Pavlovic, M., Balint, B. (2013). Short History of Stem Cells Transplantation with Emphasis on Hematological Disorders. In: Stem Cells and Tissue Engineering. SpringerBriefs in Electrical and Computer Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5505-9_1
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DOI: https://doi.org/10.1007/978-1-4614-5505-9_1
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