Gastroesophageal Reflux in Cystic Fibrosis and Non-CF Bronchiectasis

Part of the Respiratory Medicine book series (RM, volume 2)


Gastroesophageal reflux (GER) or the retrograde flow of gastric contents into the esophagus is a physiologic phenomenon that occurs most often after meals and is restricted to the distal esophagus [1, 2]. These occasional GER episodes are of brief duration, cleared rapidly, and generally well tolerated [3]. GER can be accompanied by typical symptoms, like heartburn and regurgitation, but also by atypical symptoms such as noncardiac chest pain, cough, wheezing, and ear, nose, and throat symptoms [1, 2]. Pathological GER or GERD (GER disease) has been described as the increased frequency or duration of exposure of the esophagus to regurgitated gastric contents [4]. Reflux has been clearly associated with the presence of esophagitis and Barrett’s esophagus, and it has also been implied in the pathophysiology of different respiratory disorders [5, 6]. This chapter deals with the literature data on the prevalence, mechanisms, and role of GER in cystic fibrosis as well as in non-CF bronchiectasis.


Gastroesophageal reflux (GER) Cystic fibrosis Non-CF ­bronchiectasis Aspiration of gastric content Hiatal hernia Postprandial acid pocket Gastroesophageal pressure gradient (GEPG) 


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID)University Hospital GasthuisbergLeuvenBelgium
  2. 2.Upper Gastrointestinal Physiology UnitBarts and The London School of Medicine and DentistryLondonUK
  3. 3.Department of Respiratory MedicineUniversity Hospital LeuvenLeuvenBelgium

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