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GER in Lung Transplantation

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Part of the Respiratory Medicine book series (RM, volume 2)

Abstract

Abnormal gastroesophageal reflux (GER) is present in a substantial number of patients with advanced lung disease due to a variety of causes and is especially prevalent in patients with pulmonary fibrosis or bronchiectasis. GER and microaspiration of refluxed gastroduodenal secretions have been linked to posttransplant lung allograft complications especially bronchiolitis obliterans syndrome (BOS) in which obliterative bronchiolitis (OB) can lead to progressive allograft dysfunction and loss. A considerable body of literature has linked abnormal GER to BOS, and strategies to prevent reflux may lessen the risk for developing BOS as well as diminish the risk of progression when BOS associated with abnormal GER occurs and leads to allograft functional impairment. This chapter will discuss the potential role of abnormal GER and microaspiration in the development of posttransplant allograft dysfunction and examine potential strategies to manage transplant recipients with evidence of abnormal GER.

Keywords

Abnormal gastroesophageal reflux (GER) Pulmonary fibrosis Bronchiectasis Bronchiolitis obliterans syndrome (BOS) Obliterative bronchiolitis (OB) Microaspiration 

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Department of MedicineUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA
  2. 2.Department of Surgery, Division of Cardiothoracic SurgeryUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA

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