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GER and Aspiration in Interstitial Lung Disease

Chapter
Part of the Respiratory Medicine book series (RM, volume 2)

Abstract

Many investigations have linked gastroesophageal reflux (GER) to various forms of interstitial lung disease (ILD) including idiopathic pulmonary fibrosis (IPF), scleroderma, and other connective tissue diseases (CTD). However, definitive proof that abnormal GER and microaspiration is a cause of ILD, promotes disease progression, or precipitates acute exacerbation of IPF or other forms of ILD is lacking. Nonetheless, evidence is accumulating that suggests that abnormal GER and microaspiration of refluxed gastroduodenal secretions may play a significant role in IPF, scleroderma, and other ILD. This chapter examines the published evidence and provides an assessment of the current state of knowledge of the role of GER and microaspiration in ILD.

Keywords

Gastroesophageal reflux (GER) Aspiration Interstitial lung disease Pulmonary fibrosis (IPF) Scleroderma Connective tissue diseases (CTD) Microaspiration 

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Department of MedicineUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA
  2. 2.Division of Pulmonary & Critical Care MedicineUniversity of Washington Medical CenterSeattleUSA

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