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Stem Cells and Glaucoma

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Book cover Stem Cell Biology and Regenerative Medicine in Ophthalmology

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Stem cell-based therapies provide new hope for treating glaucoma and other optic neuropathies. Transplanting stem cells or stem cell-derived cells into the retina could provide neuroprotective support to surviving neurons or potentially replace neurons that have already been lost in order to restore visual function. However, before these therapies reach patients, there is a need to identify the appropriate donor cell type(s) to use, as well as how best to differentiate and deliver these cells, to maximize integration, neuroprotection, and functional recovery in the injured retina. Here we review progress towards these goals and critical next steps to bringing stem cell therapies to glaucoma.

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Acknowledgements

This work was supported by the Department of Defense, the Hope for Vision foundation, the National Eye Institute (P30 EY014081, Miami), and an unrestricted grant from Research to Prevent Blindness. JH was supported in part by NIH T32-NS07492, and by a Lois Pope Life Fellowship. JLG is the Walter G. Ross Distinguished Chair in Ophthalmic Research.

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Authors and Affiliations

  1. Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA

    Jonathan Hertz & Jeffrey L. Goldberg

  2. Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL, USA

    Jonathan Hertz & Jeffrey L. Goldberg

  3. Neuroscience Graduate Program, Miller School of Medicine, University of Miami, Miami, FL, USA

    Jonathan Hertz

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  1. Jonathan Hertz
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  2. Jeffrey L. Goldberg
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Correspondence to Jeffrey L. Goldberg .

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  1. Edward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University, 160 Fort Washington Avenue, Room 513, New York, 10032, New York, USA

    Stephen H. Tsang

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Hertz, J., Goldberg, J.L. (2013). Stem Cells and Glaucoma. In: Tsang, S. (eds) Stem Cell Biology and Regenerative Medicine in Ophthalmology. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-5493-9_5

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