The Induction of Mixed Chimerism Using ES Cell-Derived Hematopoietic Stem Cells

  • Francesca Milanetti
  • You-Hong Cheng
  • Richard K. Burt
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

The use of haematopoietic stem cell (HSC) transplantation for the establishment of mixed chimerism generally leads to durable immune tolerance to allografts in animal models of transplantation. The development of reduced intensity regimens for achieving allogeneic haematopoietic engraftment across major histocompatibility complex (MHC) barriers and its recent application in clinical trials of kidney transplantation is encouraging. Embryonic stem cell-derived HSCs have lower immunogenicity and could, therefore, potentially be safer, inducing mixed chimerism and tolerance with minimal host pre-treatment and risk of graft versus host disease, despite crossing MHC barriers.

Keywords

Toxicity Leukemia Angiotensin Cyclosporine Cyclophosphamide 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Francesca Milanetti
    • 1
    • 2
  • You-Hong Cheng
    • 1
  • Richard K. Burt
    • 1
  1. 1.Division of Immunotherapy, Department of MedicineNorthwestern University, Feinberg School of MedicineChicagoUSA
  2. 2.Division of Clinical Immunology and RheumatologyS. Andrea University Hospital, Sapienza University of RomeRomeItaly

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